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| Efficacy of Quyu huatan xiaoliu decoction combined with leuprolide for treating patients with uterine fibroids and its effects on the microvessel density and the expressions of epidermal growth factor receptor, estrogen receptor, progesterone receptor in endometrial tissue of the patients |
| 1. Dazu District People's Hospital, Chongqing, 402360；2. The Second People's Hospital of Dazu District, Chongqing, 402360 |
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Abstract To investigate the efficacy of Quyu huatan xiaoliu decoction combined with leuprolide for treating patients with uterine fibroids, and tostudy its effects on the microvessel density and the expressions of epidermal growth factor receptor(EGFR), estrogen receptor(ER), progesterone receptor(PR)in endometrial tissue of the patients. Methods: A total of 86 patients with uterine fibroids were selected and were divided into group A and group B(43 cases in each group)by random number table method from October 2019 to February 2022. The patients in group B were given leuprolide for 3 months, and the patients in group A were given Quyu huatan xiaoliu decoction combined with leuprolide for 3 months. The TCM syndrome scores, the uterine fibroids volume, the uterine volume, and the levels of sex hormone indexes, such as estradiol(E2), progesterone(P), luteinizing hormone(LH), and follicle stimulating hormone(FSH)before and after treatment, the microvessel density, the levels of EGFR, ER, PR expression in endometrial tissue, the curative effect, and the adverse reactions of the patients were compared between the two groups. Results: After treatment, the TCM syndrome score(6.38±1.25 points), the uterine fibroid volume(6.24±1.06 cm3), and the uterine volume(95.74±10.17 cm3)of the patients in group A were significantly lower than those(9.26±1.67 pints, 9.02±1.32 cm3, and 106.25±13.08 cm3)of the patients in group B. The levels of serum E2(151.14±16.05 pmol/L), P(12.47±1.86μg/L), LH(11.06±2.57 U/L), and FSH(12.84±1.95 U/L)of the patients in group A were significantly lower than those(182.69±18.28 pmol /L, 17.04±2.09μg/L, 14.82±2.73 U/L, and 16.18±2.06 U/L)of the patients in group B. The microvessel density(26.1±3.1), the positive expression rates of EGFR(16.3%), ER(30.2%), and PR(30.2%)in endometrial tissues of the patients in group A were significantly lower than those(30.3±3.3, 37.2%, 53.5%, and 51.2%)of the patients in group B. The total effective rate(90.7%)of the patients in group A was significantly higher than that(69.8%)of the patients in group B(all P＜0.05). There was no significant difference in the incidence of adverse reactions(7.0% vs. 11.9%)of the patients between the two groups(P＞0.05). Conclusion: The application of Quyu huatan xiaoliu decoction combined with leuprolide for treating the patients with uterine fibroids can regulate the their level of sex hormones, reduce their microvessel density and the expressions of EGFR, ER and PR in the endometrial tissue, thereby promoting the regression of the lesions and improving the clinical symptoms, which is safe and effective.
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