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| Correlation between the expressions of exportin 4, kinesin family member 23, and milk fat globule epidermal growth factor 8 in endometrial carcinoma tissue of patients and their clinicopathology |
| 1.The Second Affiliated Hospital of Air Force Military Medical University, Xi'an, Shanxi Province,710038； 2. Sichuan Gemflower Hospital, Chengdu |
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Abstract To analyze the correlation between the expression levels of exportin 4 (XPO4), tissue kinesin family member 23 (KIF 23), and milk fat globule epidermal growth factor 8 (MFG-E8) in endometrial carcinoma tissue of patients and their clinicopathology. Methods: The clinical data of total 98 patients with endometrial carcinoma who received surgical treatment from January 2019 to June 2021 were collected. Immunohistochemical staining was used to detect the expressions of XPO4, KIF 23, and MFG-E8 in endometrial carcinoma tissue of these patients. The correlation between the expression levels of XPO4, KIF 23, and MFG-E8 in endometrial carcinoma tissue of these patients and their pathological parameters of endometrial carcinoma was analyzed. Results: The positive expression rate of XPO4 protein (37.8%) in endometrial carcinoma tissues of the patients was significantly lower than that (67.4%) in normal uterine tissues of the patients, and the positive expression rates of KIF 23 and MFG-E8 protein (74.5% and 81.6%) in endometrial carcinoma tissues were higher than those (17.4% and 6.1%) in the normal uterine tissues (all P＜0.05). The level of XPO4 protein in the endometrial carcinoma tissues of the patients was correlated with their tumor diameter, myometrium invasion, FIGO stage, and lymph node metastasis. The expression of KIF 23 protein of the patients was correlated with their tumor myometrium invasion, FIGO stage, and lymph node metastasis. The expression of MFG-E8 protein of the patients was correlated with their tumor diameter, myometrium invasion, FIGO stage, and lymph node metastasis (all P＜0.05). Receiver operating characteristic curve analysis showed that the expressions of XPO4, KIF 23, and MFG-E8 protein for diagnosing endometrial carcinoma were 0.841, 0.816, 0.875, respectively, respectively, with the sensitivity of 84.6%, 83.3%, and 86.6%, respectively, and with the specificity of 83.6%, 82.1%, and 83.2%, respectively. Conclusion: The expression of XPO4 protein in endometrial carcinoma tissue is low, and the expressions of KIF 23 and MFG-E8 proteins are high. The XPO4, KIF 23 and MFG-E8 expressions are closely related to the clinical pathology of endometrial carcinoma, which has certain value for clinical diagnosis of endometrial carcinoma.
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