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| Effects of GnRH-a for treating patients with moderate and severe endometriosis after laparoscopic surgery on their subseguent pregnancy |
| Dalian Maternal and Child Health Care hospital, Dalian, Liaoning Province, 116033 |
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Abstract To explore the effects of gonadotropin-releasing hormone agonist (GnRH-a) for treating patients with moderate and severe endometriosis after laparoscopic surgery on their pregnancy. Methods: A total of 114 patients with stage Ⅲ and Ⅳ of endometriosis who had all received conservative laparoscopic surgery were selected in this study from September 2017 to April 2019. These patients were divided into observation group and control group according to their wishes. The patients in the observation group had received GnRH-a injection postoperatively, and the patients in the control group were not given GnRH-a injection postoperatively. The pregnancy status of the patients during postoperative 18 months in the two groups was followed up. Results: The CA125 level and the pelvic pain scale score of the patients in the two groups in the 6th month after operation were significantly lower than those of the patients before operation (P<0.05), but which had no significantly different between the two groups (P>0.05). There was no significant difference in the recurrence rate (3.5% vs.7.0%) of the patients in the 12th month after operation between the two groups (P>0.05). The pregnancy rate (31.6%) of the patients in the observation group in the 18th month after surgery was significantly higher than that (14.0%) of the patients in the control group (P<0.05). There was no significant difference in the pregnancy rate of the patients with Ⅲ stage of endometriosis between the two groups (P>0.05), but the pregnancy rate (25.0%) of the patients with Ⅳ stage of endometriosis in the observation group was significantly higher than that (3.9%) of the patients in the control group (P<0.05). Conclusion: The application of GnRH-a after laparoscopic conservative surgery of the patients with moderate and severe endometriosis has no obvious effect on the surgical effect, but can effectively increase of their pregnant rate after operation.
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