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| Correlation between serum matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 levels of patients with intrauterine adhesions and their values of blood flow parameters examined by three-dimensional energy ultrasonic |
| The Seventh People's Hospital of Zhengzhou, Henan Province, 450000 |
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Abstract To analyze the relationship between the levels of serum matrix metalloproteinase 9（MMP-9) and tissue inhibitor of metalloproteinase 1（TIMP-1) of patients with intrauterine adhesion（IUA) and their endometrial volume and the values of blood flow parameters by examined three-dimensional energy ultrasonic.Methods: The patients with IUA were selected in study group and the women with normal uterine cavity were selected in control group from January 2018 to May 2020.According to the severity of IUA, the patients in the study group were further divided into group A（patients with mild IUA), group B（patients with moderate IUA), and group C（patients with severe IUA).The levels of serum MMP-9 and TIMP-1, endometrial volume（V), endometrial vascular index（VI), blood flow index（FI), and vascular blood flow index（VFI) of the patients were compared among these groups.And the correlation between serum MMP-9 and TIMP-1 levels of patients and their values of three-dimensional energy ultrasonic parameters was analyzed.Results: The serum MMP-9 level（10.29±3.10 mg/L) of the patients in the study group was significant lower than that（16.77±4.92 mg/L) of the women in the control group, but the serum TIMP-1 level（131.21±28.23μg/L) of the patients in the study group was significant than that（105.83±30.41μg/L) of the women in the control group.The values of VI, FI and VFI of the patients in the study group were all significant lower than those of the women in the control group（P<0.05).The serum MMP-9 level, and the values of V, VI and VFI of the patients in group A, group B, and group C were decreased gradually, while the serum TIMP-1 level was increased gradually（P<
0.05).There was no significant difference in FI value of the patients between group C and group B（P＞0.05).The level of serum MMP-9 was negatively correlated with the degree of IUA, while the level of TIMP-1 was positively correlated with the degree of IUA（P<0.05).The serum MMP-9 level was positively correlated with the values of V and VFI, but the serum TIMP-1 level was negatively correlated with the values of V and VFI（P<0.05), and the serum MMP-9 and TIMP-1 levels were no correlated with the values of VI and FI（P＞0.05).Conclusion: The serum MMP-9 level decrease and TIMP-1 level increase with the aggravation of IUA, which are correlated with the rate of endometrial V type and the values of the blood flow parameters.
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