To analyze the abnormal changes of neutrophil to lymphocyte ratio (NLR) and the hypersensitive C-reactive protein (hs-CRP) level of pregnant women, and to study their values for predicting the occurrence of hypertensive disorders of pregnancy (HDP). Methods: 133 pregnant women with HDP were selected in study group from October 2016 to October 2019, and 266 normal pregnant women were selected in control group. The women in the study group were further divided 44 cases with gestational hypertension in group A, 68 cases with mild preeclampsia in group B, and 21 cases with severe preeclampsia in group C. The differences of white blood cell count (WBC), neutrophil count (N), lymphocyte count (L), the NLR value, and the hs-CRP level of the women were compared among these groups. The risk factors of HDP and the predictive value of the NLR value and hs-CRP level for HDP were analyzed. Results: The values of WBC, N, L, and NLR, and the hs-CRP level of the women in the study group were significantly higher than those of the women in the control group, and the values of WBC, N, and NLR, and the hs-CRP level of the women in group B and C were significantly higher than those of the women in group A (P<0.05). There were no significant differences in the values of WBC, N, L, and NLR, and the hs-CRP level of the women between group B and group C (P>0.05). Age ≥35 years old, the body mass index >28kg/m2, the WBC value, the NLR value, and the hs-CRP level of the women were the independent risk factors of HDP (P<0.05). The NLR value and Hs-CRP level had some predictive effects for HDP (P<0.05). Conclusion: The NLR value and HS-CRP level in peripheral blood of the pregnant women during the first trimester of pregnancy are related to the HDP occurrence of these women, which have some predictive value for HDP.