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| Expression of serum CXCR4 of pregnant women with preeclampsia and its relevant with their inflammatory factors levels |
| The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, 450014 |
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Abstract To investigate the role of SDF-1/CXCR4 axis in the inflammatory pathogenesis of pregnant women with preeclampsia. Methods: From January 2020 to October 2020, 30 pregnant women delivered by cesarean section because of severe preeclampsia were recruited in observation group. Meanwhile, 30 healthy pregnant women were randomly selected in control group. The expressions of CXCR4 and NF-κBp65 mRNA in serum of the women in the two groups were detected by RT-PCR. The levels of inflammatory factors, such as interleukin(IL)-6, tumor necrosis factor-a(TNF-a), high–sensitivity C-reactive protein (hsCRP), of the women in the two groups were measured by ELISA. Pearson method was used to analyze the correlation between the serum CXCR4 and NF-κBp65 levels of the women and their inflammatory factors levels. Results: The expression level of CXCR4 mRNA of the women in the observation group was significantly lower than that of the women in the control group, while the expression level of NF-κBp65 mRNA of the women in the observation group was significantly higher (all P<0.05). The serum levels of inflammatory factors (IL-6, TNF-A, and hsCRP) of the women in the observation group were significantly higher than those of the women in the control group (P<0.05). In the observation group, the CXCR4 mRNA level of the women was negatively correlated with their NF-κBp65 mRNA level (r=-0.857, P=0.007), and also was negatively correlated with their IL-6 level, TNF-a level, and hsCRP level (r=-0.763，P=0.010; r=-0.894，P=0.006; r=-0.904，P=0.005). Conclusion: The low expression of the serum CXCR4 level of the pregnant women with severe preeclampsia may lead to the activation of NF-κB pathway and to the releasing of varieties of inflammatory factors into the maternal blood circulation. Therefore, it is speculated that SDF-1/CXCR4 axis may play an important role in the inflammatory pathogenesis of preeclampsia, and the abnormal expression of SDF-1/CXCR4 may have detrimental impacts on the maternal and fetal health.
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