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| The changes and the clinical significance of the coagulation indexes and inflammatory factor level of women with moderate or severe endometriosis |
| Jiangbei Branch of Zhongda Hospital Affiliated to Southeast University, Nanjing, Jiangsu Province, 210000 |
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Abstract To analyze the changes and the clinical significance of the coagulation indexes and inflammatory factor level of women with moderate or severe endometriosis (EMs). Methods: 210 women with moderate or severe EMs were selected in study group and 60 healthy women were included in control group from January 2018 to May 2021. The levels of coagulation indexes, such as activated partial thrombin time (APTT), prothrombin time (TT), thrombin time (PT), fibrinogen (FIB), and D-dimer (D-D), and the inflammatory factors, such as tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8), and transforming growth factor β1 (TNFβ1), of the women in the two groups were detected. Results: The values of PT and TT of the women in the study group were significantly shorter than those of the women in the control group, while the levels of FIB, D-D, TNF-α, TNF-β1, and IL-8 of the women in the study group were significantly higher (P<0.05), there was no significant difference in the APTT value of the women between the two groups (P>0.05). In the study group, the PT value of the women with EMs stage Ⅳ was significantly shorter than that of the women with EMs stage Ⅲ, but the levels of FIB, D-D, TNF-α, TNF-β1, and IL-8 of the women with EMs stage Ⅳ were significantly higher than those of the women with EMs stage Ⅲ. In the study group, the values of PT and TT of the women had decreased with the increase of adhesion degree, while the levels of FIB, D-D, TNF-α, TGF-β1, and IL-8 of the women had increased with the increase of adhesion degree, and the levels of TNF-α, TGF-β1, and IL-8 of the women had increased with the increase of pain degree (all P<0.05). The PT value of the women with EMs was negatively correlated with their clinical stage and pelvic adhesion. The levels of FIB, DD, TNF-α, TGF-β, and IL-8 of the women with EMs were positively correlated with their clinical stage of EMs and their pelvic adhesion. The levels of TNF-α, TGF-β, and IL-8 of the women with EMs were positively correlated with their pain degree (all P<0.05). Conclusion: The women with moderate and severe EMs have the abnormal blood coagulation and inflammation indicators, which are related to their EMs staging and their pelvic adhesions. EMs-related pain of the women is related to their inflammatory factors, but not significantly related to their coagulation indicators.
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