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| Value of the anti-Müllerian hormone level of women with polycystic ovary syndrome for predicting their response to ovarian stimulation after treatment of ovulation induction |
| Chongqing Institute of Population and Family Planning Science, Chongqing, 400020 |
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Abstract To analyze the value of the anti-Müllerian hormone (AMH) level of women with polycystic ovary syndrome (PCOS) for predicting their response to ovarian stimulation after treatment of ovulation induction by clomiphene citrate tablets (CC) and human menopausal gonadotrophin (hMG). Methods: A total of 77 women with PCOS were selected and were given ovulation induction treatment by CC combined with hMG from January 2019 to June 2020. These women were divided into group A (56 women with response of ovarian) and group B (21 women without response of ovarian) according to the results after ovarian stimulation by CC combined with hMG. The clinical data and the AMH level of the women were compared between the two groups. ROC curve was used to analyze the value of the AMH level of the women for predicting their response to ovarian stimulation by CC combined with hMG. Results: After ovulation induction treatment by CC combined with hMG, the serum AMH level of the women (21 cases, 11.76±2.90 ng/ mL) in group B was significantly higher than that (56 cases, 8.24±2.15 ng/ml) of the women in group A (P<0.05), but the levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), LH/FSH, progesterone (P), and testosterone (T) of the women had no significant different between the two groups (P>0.05). ROC curve analysis showed that the area under the curve of the serum AMH level of the women with PCOS for predicting their response to ovarian stimulation was 0.901, the optimal limit cut-off value of the serum AMH level was 9.72ng/mL, and which sensitivity and specificity were 76.8% and 90.5%, respectively. Conclusion: The AMH level of the women with PCOS can effectively predict the response to ovarian stimulation after treatment by CC combined with and hMG.
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