|
|
|
| The correlation and clinical significance of retinol binding protein-4, interleukin-1β, and vascular endothelial growth factor expressions of obesity women with polycystic ovarian syndrome |
| The First Hospital of Wuhan, Wuhan, Hubei Province, 430022 |
|
|
|
|
Abstract To explore the clinical significance of retinol binding protein-4 (RBP-4), interleukin-1β(IL-1β), and vascular endothelial growth factor(VEGF) expressions of obesity women with polycystic ovarian syndrome (PCOS). Methods: 80 obesity (body mass index ≥28kg/m2) women with PCOS were selected in observation group and 80 obesity women without PCOS who had the same age were selected in control group from January 2017 to April 2020. The venous bloods of the women in the two groups were collected for analyzing the expression levels of serum RBP-4, IL-1β and VEGF. Results: The levels of RBP-4 (35.1±6.5μg/ml), IL-1β(11.9±3.4pg/ml), and VEGF (553.3±58.6 ng/ml) of the women in the observation group were significant higher than those（27.4±3.5μg/ml, 8.6±1.9 pg/ml, and 412.5±76.2ng/ml） of the women in the control group, and which of the women with ovulation dysfunction in the observation group were significant higher than those of the women without ovulation dysfunction (all P<0.05). The RPB-4 level, IL-1βlevel, and VEGF3 level of the women in the observation group were positive correlation each other (all P<0.05). Conclusion: RPB-4, IL-1β and VEGF maybe involve in the occurrence and development of PCOS by regulating the inflammatory response, the triglyceride metabolism, and the risk of ovulatory dysfunction increased by angiogenesis.
|
|
|
|
|
|
|
|
|
