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| The relationship between the mismatch repair protein expression level of patients and their different types of endometrial lesions |
| 1. The First Affiliated Hospital of North University, Zhangjiakou, Hebei Province,075000; 2. Zhangjiakou Infectious Disease Hospital |
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Abstract To investigate the relationship between the mismatch repair (MMR) gene expression level of patients and their endometrial lesions. Methods: 180 patients with endometrial lesions from January 2017 to December 2019 were collected retrospectively, which included 60 patients with endometrial polyp in group A, 60 patients with endometrial atypical hyperplasia in group B, and 60 patients with endometrial cancer in group C. Tissue samples of the patients in the three groups were collected for detecting MMR protein expression level. The expression level of MMR protein in endometrial lesions tissues and the difference of the MMR protein expression and clinicopathological indexes in endometrial cancer tissue of the patients were analyzed. Among the three groups, the age and the incidence of deficiency of MMR (33.3%) of the patients in group C were the highest. The incidence of deficiency of MLH1 (23.3%) and the level of PMS2 (23.3%) of the patients in group C were also the highest, and which were significant higher than those of the patients in group A and B (P<0.05). The incidence of deficiency of MMR in endometrial cancer tissue was associated with the increased muscular invasion of cancer (P<0.05). Conclusion: MMR protein plays an important role in the occurrence and development of endometrial lesions.
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