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| Changes of the levels of negative regulator of cytokine signaling 3, liver X receptor α, vascular placenta growth factor of pregnant women with pregnancyinduced hypertension and preeclampsia, and which predictive value for preeclampsia |
| Zigong Maternal and Child Health Care Hospital, Zigong, Sichuan Province, 643000 |
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Abstract To explore the changes of the levels of negative regulator of cytokine signaling 3 (SOCS3), liver X receptor α (LXRα), vascular placenta growth factor (PLGF) of pregnant women with pregnancy-induced hypertension and preeclampsia, and to analyse their predictive value for preeclampsia. Methods: A prospective study design was conducted. 120 pregnant women patients with pregnancy-induced hypertension and preeclampsia were selected in study group from January 2016 to December 2019, and 118 normal pregnant women were selected in control group during the same period. Enzyme-linked immunosorbent assay (ELISA) was used to detected the expression levels of serum SOCS3, LXRα, and PLGF of the women. Logistic regression model combined with receiver operating characteristic (ROC) curve was used to evaluate the values of the expression levels of serum SOCS3, LXRα, and PLGF for diagnosing pregnancy-induced hypertension and preeclampsia. Results: The levels of serum SOCS3 and PLGF of the women in the study group were significant lower than those of the women in the control group, but the LXRα level of the women in the study group was significant higher (P<0.001). ROC curve analysis showed that when the cutoff value of SOCS3 level, LXRαlevel, and PLGF level were 0.32 ng/L, 178.26 ng/L, and 41.56 pg/ml, the levels of SOCS3, LXRα, and PLGF had some diagnostic value for preeclampsia. The combination detections of the levels of SOCS3, LXRα, and PLGF could improve the diagnostic efficiency (P<0.05), which sensitivity, specificity, and Youden index were 70.3%, 81.7%, and 0.520, and which area under the ROC curve was 0.895 (95% CI: 0.811-0.947). Conclusion: The serum LXRα expression of the pregnant women with pregnancy-induced hypertension and preeclampsia increases abnormally, and their serum PLGF and SOCS3 expression levels decrease abnormally. The combination detections of the levels of SOCS3, LXRα, and PLGF can improve the diagnostic efficiency.
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