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| Changes of vitamin D and parathyroid hormone levels of women with gestational diabetes mellitus and analysis of the related factors |
| Danzhou People's Hospital, Hainan Province, 571700 |
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Abstract To analyze the changes of vitamin D and parathyroid hormone (PTH) levels of women with gestational diabetes mellitus (GDM), and to study the influencing factors. Methods: Pregnant women with GDM were selected in study group and normal pregnant women were selected in control group from February 2017 to April 2020. The fasting venous bloods of these women were collected when empty stomach for detecting their serum 25 (OH) D3 and PTH levels. In the study group, the women were further divided into group A1 (women with severe vitamin D deficiency), group A2 (women with mild vitamin D deficiency), and group A3 (women without vitamin D deficiency) according to whether or not of vitamin D deficiency. In the study group, the women were further divided into group B1 (women with low level of PTH), group B2 (women with middle level of PTH), and group B3 (women with high level of PTH) according to the PTH level of the women. The serum 25(OH)D3 and PTH levels of the women were compared among these groups, and the related factors of vitamin D deficiency and high PTH levels of the women were analyzed. Results: The serum levels of 25 (OH) D3 of the women in the study group was significant lower than that of the women in the control group. The proportion of the severe or mild vitamin D deficiency, and the serum PTH level of the women in the study group were significant higher than that of the women in the control groups (P<0.001). The age and the proportion of the curve of OGTT time-glucose (AUCglu) ≥16.8mmol/L/h, and the value of insulin resistance ratio index (HOMA-IR) of the women in group A3, group A2, group A1 had increased gradually (P<0.05). The values of body mass index (BMI), fasting plasma glucose (FPG), glucose tolerance test OGTT (1 h), OGTT (2 h) of the women in group A1 were significant higher than those of the women in group A2 and group A3 (P<0.05), but which had no significant difference between group A2 and group A3 (P>0.05). The proportion of multipara had no significant difference among groupA1, group A2, and group A3 (P>0.05). The proportion of AUCglu ≥16.8mmol/L/h, and the values of FPG and HOMA-IR of the women in group B1, group B2, group B3 had increased gradually, and the age, the OGTT (2h) value of the women in group B2, group B3 were significant higher than those of the women in group B1 (P<0.05). The age and the OGTT (2h) value of the women had no significant difference between group B2 and group B3 (P>0.05). The OGTT (1h) value of the women in group B3 was significant higher than that of the women in group B1 (P<0.05). The BMI value and the proportion of multipara had no significant difference among groupB1, group B2, and group B3 (P>0.05). Age ≥35 years old, AUCglu ≥16.8mmol/L/h, and HOMA-IR value of the women were associated with their severe or mild vitamin D deficiency and their higher level of PTH. The OGTT (2 h) value of the women was associated with their higher level of PTH (all P<0.05). Conclusion: The proportion of vitamin D deficiency and the level of PTH of pregnant women with GDM are high, especially for those women with older age, disordered glucose metabolism, and severe insulin resistance.
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