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| Clinical value of three-dimensional ultrasonic measurement of endometrial volume and blood flow status in women with luteal phase defect infertility |
| Sichuan Provincial Maternity and Child Health Care Hospital, Chengdu, Sichuan Province, 610000 |
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Abstract To explore the clinical significance of the endometrial volume and blood flow status of patients with luteal phase defect infertility analyzed by three-dimensional ultrasound. Methods: 40 women with luteal phase defect infertility were selected in study group and 40 healthy women were selected in control group from January 2019 to December 2019. The women in both groups were examined by conventional two-dimensional ultrasound and three-dimensional ultrasound. The ultrasound measurement parameters during ovulation phase and mid-luteal phase of the women in the two groups were analyzed. The results by twodimensional ultrasound included endometrial thickness, peak systolic velocity (PSV) of uterine spiral artery blood flow, pulsatility index (PI), and resistance index (RI), and the results by three-dimensional ultrasound included endometrial volume, and vascular index (VI), blood flow index (FI), and vascular blood flow index (VFI) of endometrium and subendometrium. Results: There were no significant differences in PSV and PI values of uterus spiral arteries in periovulatory and luteal mid phase, and RI value of uterus spiral arteries in periovulatory of the women between the two groups (P>0.05). The RI value of the women in the study group in luteal mid phase (1.01±0.09) was significant higher than that (0.93±0.14) the women in the control group (P<0.05). The endometrial volume, and the values of endometrial and subendometrial VI, FI, and VFI during ovulation of the women had no significant different between the two groups (P>0.05). In luteal mid phase, endometrial volume (4.03±1.20 ml) of the women in the study group was significant lower than that (5.71±1.98 ml) of the women in the control group, and subendometrial FI and VFI values (24.98±3.22 and 2.30±0.56) of the women in the study group were significant lower than those (29.31±3.74 and 2.91±0.99) of the women in the control group (P<0.05). Correlation analysis showed that endometrial volume of the women in the study group in luteal mid phase was positively correlated with their endometrial VI, FI, and VFI values, and their subendometrial VI, FI, and VFI values (P<0.05). ROC curve analysis showed that the area under the curve of RI value, endometrial volume, subendometrial FI and VFI values of uterus spiral arteries of the women in luteal mid phase for diagnosing luteal phase defect infertility were 0.706, 0.761, 0.800, and 0.697, respectively, which’s sensitivity were 95.0%, 92.5%, 87.5%, and, 95.0%, respectively, and which’s specificity were 50.0%, 60.0%, 62.5%, and 42.5%, respectively. Conclusion: Three-dimensional ultrasound can evaluate the endometrial receptivity and blood flow status of the women with luteal phase defect infertility. Endometrial volume and subendometrial FI value of the women have certain clinical application value for diagnosing luteal phase defect infertility.
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