To investigate the influence of combined spinal-epidural anesthesia and epidural anesthesia during cesarean section of the women with pregnancy induced hypertension on their stress response and inflammatory factors levels. Methods: A total of 120 pregnant women with pregnancy induced hypertension who underwent cesarean section were selected as the research subjects and were randomly divided into observation group and control group (60 cases in each group) by the random number table from March 2017 to March 2020. The women in the control group were treated with simple epidural anesthesia, while the women in the observation group were treated with combined spinal-epidural anesthesia. The changes of the levels of serum inflammatory factors indexes, such as cortisol (Cor), malondialdehyde (MDA), superoxide dismutase (SOD), total antioxidant capacity (TAC) stress response, high sensitivity C reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), and interleukin -6(IL-6), of the women at 1 h before anesthesia (T0), at the end of surgery (T1), and at 24 h after surgery (T2) of the women were compared between the two groups. Results: The values of hemodynamic indexes, such as HR, DBP, SBP, and MAP, of the women at T0 had no significant different between the two groups (P>0.05). At T1, the values of HR, DBP, SBP, MAP of the women in the two groups were significant lower than those of the women at T0, and those of the women in the observation were significant lower than those of the women in the control group (P<0.05). There were no significant differences in levels of serum Cor, MDA, SOD, TAC, hs-CRP, TNF-α, and IL-6 of the women between the two groups (P>0.05). At T1 and T2, the levels of serum Cor, MDA, TAC, hs-CRP, TNF-α, and IL-6 of the women in the two groups were significant higher than those at T0, while the SOD level at T1 and T2 were significant lower (all P<0.05). At T2, the levels of serum Cor, MDA, TAC, hs-CRP, TNF-α, and IL-6 of the women in the two groups were significant higher than those at T1, while the SOD level at T2  was significant lower (all P<0.05). At T1 and T2, the levels of serum Cor, MDA, TAC, hs-CRP, TNF-α, and IL-6 of the women in the observation group were significant higher than those of the women in the control group, while the SOD level of the women in the observation group was significant lower (all P<0.05). Conclusion: Combined spinal-epidural anesthesia during cesarean section of the women with pregnancy induced hypertension can more improve the hemodynamic indicators of the women, inhibit the stress response and the release of inflammatory factors effectively, which is conducive to their anesthesia and postoperative recovery.