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| Evaluation of anesthesia effect and safety of different dosages of sufentanil combined with propofol during hysteroscopic surgery |
| Sanya People's Hospital, Sanya, Hainan Province, 572000 |
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Abstract To observe the anesthesia effect and safety of three dosages of sufentanil combined with propofol during hysteroscopic surgery. Methods: 99 patients who wanted elective hysteroscopic surgery were selected and were divided in three groups (33 cases in each group) by random number table method from June 2018 to June 2020. All these patients were given 2.0mg/kg propofol for sedation. And the patients in group I, II, and III were also given intravenous injection of sufentanil 0.15ug/kg, 0.20ug/kg, and 0.25ug/kg, respectively. The anesthesia effects, the values of the hemodynamic indexes, such as heart rate (HR), blood oxygen saturation (SpO2), and mean arterial pressure (MAP) before anesthesia (T0), when the cervix dilated (T1), during the operation (T2), in the end of the operation (T3), and when awake after the operation (T4), and the rate of adverse reactions during surgical anesthesia of the patients were compared among the three groups. Results: The anesthesia work time of the patients had no significant different between group II and group III, but which was significant shorter than that of the patients in group I. The time of postoperative consciousness recovery and the dosage of propofol of the patients in group I, II, III had increased gradually (P<0.05). There were no significant different in postoperative 1h Ramsay score and VAS score of the patients among the three groups (P>0.05). The values of HR, MAP, and SpO2 of the patients in the three groups at T1, T2 and T3 were significant lower than those at T0 (P<0.05). There were no significant different in the values of HR, MAP, and SpO2 of the patients among T1, T2, T3, T4 (P>0.05). At T1, the HR value of the patients in group III was significant lower than that of the patients in group I and II, the MAP value of the patients in group II and III was significant lower than that of the patients in group I, and the SpO2 value of the patients in group II was significant lower than that of the patients in group I (P<0.05). At T2, the HR value of the patients in group II and III was significant lower than that of the patients in group I, the MAP value of the patients in group II and III was significant lower than that of the patients in group I and III, and the SpO2 value of the patients in group II was significant lower than that of the patients in group I and III (P<0.05). At T3, the HR value of the patients in group III was significant lower than that of the patients in group I and II, the MAP value of the patients in group II and III was significant lower than that of the patients in group I, and the SpO2 value of the patients in group III was significant lower than that of the patients in group I (P<0.05). There were no significant different in the incidence of adverse reactions (12.1% vs.15.2% vs.18.2%) among the three groups (P>0.05). Conclusion: 0.15ug/kg sufentanil combined with propofol used during hysteroscopic surgery of the patients has little effect on their hemodynamic change, which has advantages of awaken up quickly and significant postoperative analgesic and sedative effect with less dosage of propofol, and which is worthy of clinical application because of its safety and effectiveness of anesthesia.
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