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Abstract To explore the expression of DNA methyltransferase 3B (DNMT3B), matrix metalloproteinase-2 (MMP-2), and epithelial neutrophil-activating peptide 78 (ENA78) in endometriosis tissue of women, and to study their correlation with the endometriosis occurrence. Methods: 51 women with endometriosis were selected in study group and 37 healthy women were selected in control group from March 2017 to October 2020. Immunohistochemistry was used to evaluate the expressions of DNMT3B, MMP-2, and ENA-78 in ectopic and eutopic endometrial tissues of the women in the study group and in normal endometrial tissues of the women in the control group. The correlation analysis and diagnostic efficacy analysis were performed. Results: The expression positive rate of DNMT3B (84.3%), MMP-2 (90.2%), and ENA-78 (80.4%) in ectopic endometrium of the women in the study group were significant higher than those in eutopic endometrial tissues of the women in the study group and in normal endometrial tissues of the women in the control group (P<0.05). In ectopic endometrium of the women in the study group, the MMP-2 expression were positively correlated with the expressions of DNMT3B and ENA-78 (P<0.05). AUC of the combination detections of DNMT3B, MMP-2, and ENA-78 for diagnosing endometriosis was 0.924, which accuracy (92.0%) were significant higher than that (75.0%) of DNMT3B alone, that (76.1%) of MMP-2 alone, or that (72.7%) of ENA-78 alone (P<0.05). Conclusion: The positive rates of DNMT3B, MMP-2, and ENA-78 in ectopic endometrium of the women with endometriosis increase significantly, and the combination detections of DNMT3B, MMP-2, and ENA-78 can provide evidences for diagnosing endometriosis.
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