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| Serum anti-mulleler tube hormone level combined with endometriosis fertility index score for predicting the pregnancy outcomes of infertility women with endometriosis who had been treated by intrauterine insemination after laparoscopic surgery |
| 1. Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi Province, 712000；2.The Third People's Hospital of Baoji, Shaanxi Province；3. The First Affiliated Hospital of Xi'an Jiaotong University |
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Abstract To investigate value of serum anti-mulleler tube hormone (AMH) combined with endometriosis fertility index (EFI) score for predicting the pregnancy outcomes of infertility women with endometriosis (EMS) who had been treated by intrauterine insemination (IUI) after laparoscopic surgery. Methods: 103 infertile women with EMS who underwent laparoscopic surgery were enrolled in this study from March 2017 to March 2020. According to the pregnancy outcomes, these women were divided group A (48 women without pregnancy) and group B (55 women with pregnancy). The women in the two groups were treated by IUI in their ovulation induction cycle for assisted pregnancy after laparoscopic surgery. The general information and pregnancy outcomes of all these women were collected. The AMH level of these women was measured, and their EFI score was evaluated. The AMH level and EFI score of the women were compared between the two groups. Logistic regression was used to analyze the influencing factors of the cumulative pregnancy rate after IUI. The predictive value of AMH level and EFI score for the cumulative pregnancy rate was analyzed by receiver operating characteristic curve. Results: The postoperative AMH level (2.18±0.76ng/ml) and EFI scores (5.48±1.54 points) of the women in group A were significant lower than those (2.87±0.84ng/ml and 6.78±1.48 points) of the women in group B (P＜0.05). The cumulative pregnancy rate of the women with 7-10 points of EFI score was significant higher than that of the women with 0-6 points of EFI score (P＜0.05). The postoperative AMH level and EFI score of the women were positively correlated with their cumulative pregnancy rate, which were the independent risk factors affecting the cumulative pregnancy rate (all P＜0.05). The sensitivity, the specificity, and AUC of postoperative AMH level combined with EFI score for predicting the cumulative pregnancy rate of IUI were 76.4%, 95.8%, and 0.944, respectively. Conclusion: Postoperative AMH level combined with EFI score can predicting pregnancy outcomes of women with IUI after laparoscopic surgery, and both of the AMH level and EFI score are independent risk factors influencing cumulative pregnancy rate of IUI after laparoscopic surgery.
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