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| Correlation between the levels of serum alpha fetoprotein, free-β-human chorionic gonadotropin, unconjugated estriol and adverse pregnancy outcomes in elderly pregnant women |
| Fuyang Women and Children's Hospital, Anhui Province, 236000 |
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Abstract To explore the correlation between the levels of serum of alpha fetoprotein (AFP), freeβhuman chorionic gonadotropin (FβHCG), and unconjugated estriol (uE3) of elderly pregnant women and their adverse pregnancy outcomes. Methods: 620 elderly pregnant women (≥35岁 years old) were selected as the research objects from February 2019 to February 2020. The average age of these pregnant women was 34.8±4.6 years old and their average gestational weeks was 18.5±0.8 weeks. After the hospital delivery medical records of these women were checked, and if necessary, inquiries by telephone had conducted, the pregnancy outcomes of these pregnant women were identified. According to pregnancy outcomes, these women were divided into group A (508 women with normal pregnancy outcomes) and group B (112 women with adverse pregnancy outcomes). The levels of serum AFP, F-β-HCG, and uE3 of the women in the two groups during the second trimester of pregnancy were detected by radioimmunoassay. Results: In these 620 women, there were 458 women with normal levels of AFP, F-β-HCG, and UE3. There were 162 women (26.1%) had with abnormal levels of single or multiple serum markers, among them, the ratio of the women with single AFP level abnormality was 7.6%, the ratio of the women with single level abnormality was 7.3%, the ratio of the women with single level UE3 abnormality was 6.8%, and the ratio of the women with multiple serum markers levels abnormalities was 4.5%. In the women with single AFP level abnormality, the incidence of adverse pregnancy outcomes of the women with higher AFP level was 55.6%. In the women with single F-β-HCG level abnormality, the incidence of adverse pregnancy outcomes of the women with higher F-β-HCG level was 68.4%. In the women with single uE3 level abnormality, the incidence of adverse pregnancy outcomes of the women with higher uE3 level was 75.8%. In the women with multiple serum markers levels abnormalities, the incidence of adverse pregnancy outcomes of the women was 85.7%. Compared with those of the women in group A, the incidences of preeclampsia, poor placenta, premature rupture of membranes, neonatal asphyxia, preterm delivery, gestational diabetes mellitus, and gestational hypertension of the women in group B were significant higher (P<0.05). Conclusion: The levels of serum AFP, F-β-HCG, and uE3 of elderly pregnant women are abnormal, which can be used as the evidences for evaluating and predicting the adverse pregnancy outcomes of the women in clinic.
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