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Abstract To investigate the results of prenatal maternal immunohematology of Rh-negative pregnant women, and to study the influence of anti-D immunoglobulin application on the maternal and infant outcomes. Methods: The clinical data of 98 Rh-negative pregnant women from May 2016 to June 2020 were analyzed retrospectively. All of these women had undergone immunohematological examination before delivery. According to whether anti-D immunoglobulin application, these women were divided into group A (52 women given anti-D immunoglobulin) and group B (46 not given anti-D immunoglobulin). The postpartum hemorrhage rate, neonatal Apgar score, pregnancy outcomes (neonatal infection, neonatal anemia, neonatal hyperbilirubinemia, and the incidences of premature birth, stillbirth, neonatal RhD-negative blood type, and neonatal hemolytic disease of the newborn (HDN) were compared between the two groups. Results: In 98 Rh-negative pregnant women, there were 93 (94.9%) women with D negative, 5 (5.1%) women with variability D negative. In the D negative women, there were 50 (53.8%) CCEE phenotype, 33 (35.5%) women with CCEE phenotype, 6 (6.5%) women with CCEE phenotype, 3 (3.2%) women with CCEE phenotype, and 1 (1.1%) woman with CCEE phenotype. Among 93 Rh (D) negative pregnant women, 18 cases (19.4%) were positive for anti-D antibody, and the detection rate of the women in group A was 3.9% (2 cases), which was significant lower than that(34.8%, 16 cases) of the women in group B (χ2=15.580, P<0.05). The postpartum blood loss of the women in group A was significant lower than that of the women in group B, the Apgar score of the neonates in group A was significant higher than that of the neonates in group B. The incidences of neonatal anemia and hyperbilirubinemia, preterm delivery, and the total incidence of HDN in group A were significant lower than those in group B (all P<0.05). There were no significant differences in the incidences of neonatal infection, stillbirth, and RhD negative blood of newborns between the two groups (P>0.05). Conclusion: The Rh antigen of Rh-negative pregnant women is more common in the ccee phenotype, followed by the Ccee phenotype. Anti-D immunoglobulin can be injected to avoid the anti-D antibodies production by alloimmunization, and can improve the maternal and infant outcomes.
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