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| Correlation between the maternal serum free β-hCG and uE2 levels of pregnant women and their pregnancy complications and its influence on the pregnancy outcomes |
| 1.Guang'an People's Hospital, Guang'an, Sichuan Province, 638500；2.The Seventh People's Hospital of Chengdu |
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Abstract To study the correlation between the maternal serum freeβ-human chorionic gonadotropin (β-hCG) and urine estradiol (uE2) levels of pregnant women and their pregnancy complications, and to analyze its influence on the pregnancy outcomes of the women. Methods: The clinical data of 200 pregnant women who had completed prenatal examinations and delivered successfully between January 2018 and February 2020 were analyzed retrospectively. The maternal serum free β-hCG and uE2 levels of the women during the second trimester of pregnancy were detected. And then, according to the free β-hCG and uE2 levels, these women were divided into different groups. The differences of pregnancy complications and pregnancy outcomes of the women in these different groups were analyzed. Results: The incidences of gestational hypertension, gestational diabetes, placental abruption, premature rupture of membranes, and fetal distress of the women withβ-hCG >2.0MoM were significant higher than those of the women withβ-hCG 0.5-2.0MoM and those of the women withβ-hCG <0.5MoM (P<0.05), but which had no statistically significant different between the women withβ-hCG 0.5-2.0MoM and the women withβ-hCG <0.5MoM (P>0.05). The incidences of gestational hypertension, placental abruption, premature rupture of membranes, and fetal distress of the women with serum uE2 <0.7MoM were significant higher than those of the women with serum uE2≥0.7MoM (P<0.05). Spearman correlation analysis showed that the high-level of serum β-hCG and the low-level of serum uE2 of the pregnant women were positively correlated with the incidences of their gestational hypertension, gestational diabetes, fetal distress, premature rupture of membranes, and placental abruption (P<0.05). Conclusion: The high-level of serum β-hCG and the low-level of serum uE2 of the pregnant women are closely related to their pregnancy complications and pregnancy outcomes. It is suggested that the detections of serum β-hCG and uE2 levels of the pregnant women during the second trimester of pregnancy have positive significance to prevent pregnancy complications and adverse pregnancy outcomes.
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