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| Expression and clinical significance of serum monocyte chemoattractant protein-1, platelet endothelial cell adhesion molecule-1, and tissue factor in women with pregnancy-induced hypertension syndrome |
| 1. West Branch of Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100043；2. Shijingshan Hospital of Beijing |
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Abstract To detect the serum monocyte chemoattractant protein-1 (MCP-1), platelet endothelial cell adhesion molecule-1 (PECAM-1), and tissue factor (TF) expression levels of pregnant women with pregnancy-induced hypertension syndrome (PIH), and to analyze their relationship with the coagulation indicators levels of the women. Methods: From March 2018 to January 2021, 200 pregnant women with PIH were selected in research group. During the same period, 200 normal pregnant women were selected in control group. The women in the research group were further divided into group A (women with hypertension), group B (women with mild preeclampsia), and group C (women with severe preeclampsia). Enzyme-linked immunosorbent assay (ELISA) was used to detect the serum levels of MCP-1, PECAM-1, and TF of the women in these groups, and automatic coagulometer was used to detect the levels of prothrombin time (PT), activated partial prothrombin time (APTT), thrombin time (TT), fibrinogen (Fg), and D-dimer (D-D) in plasma of the women in these groups. Pearson analysis was used to analyze the correlation between the levels of serum MCP-1, and PECAM-1 of the women with PIH and their plasma PT, APTT, TT, Fg, and D-D levels. Results: Compared with those of the women in the control group, the serum MCP-1 and TF levels, plasma FG and D-D levels of the women in the research group were significant higher, but the serum PECAM-1 level and the plasma PT, APTT and TT levels were significant lower (P<0.05). Compared with those of the women in group A, the serum MCP-1 and TF, and plasma FG level of the women in group B and C, and the plasma D-D level of the women in group C were significant higher, but the levels of serum PECAM-1, and plasma APTT and TT of the women in group B and C were significant lower (P<0.05). Compared with those of the women in group B, the levels of serum MCP-1 and TF, and plasma FG of the women in group C were significant higher, but the serum PECAM-1 level, and the plasma APTT and TT values of the women in group C were significant lower (all P<0.05). In the research group, serum MCP-1 and TF levels of the women were negatively correlated with their plasma APTT and TT values, and were positively correlated with their Fg and D-D levels. The PECAM-1 level of the women in the research group was positively correlated with their plasma APTT and TT levels, and was negatively correlated with their FG and D-D levels (all P<0.05). The serum MCP-1 and TF of the women in the research group were negatively correlated with their PECAM-1 level, and their MCP-1 level was positively correlated with their TF level (all P<0.05). Conclusion: The serum levels of MCP-1 and TF of the women with PIH are high, while the PECAM-1 level is low, and the changes of which increase as PIH worsen. The levels of MCP-1, TF and PECAM-1 of the women with PIH are closely related each other, and all of them are also related to the coagulation indicators levels of the women, so which may have certain diagnostic value in clinical practice.
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