Abstract To evaluate the value of umbilical artery ultrasound blood flow parameters by ultrasound and serum inflammatory factor levels, such as interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP), of the pregnant women during the second trimester of pregnancy for predicting their preeclampsia. Methods: By retrospective analysis, 37 pregnant women with preeclampsia from January 2019 to June 2020 were included and were divided 17 cases with severe preeclampsia in group A and 20 cases with mild preeclampsia in group B, and 50 healthy pregnant women during the same period were included in group C. The values of umbilical artery ultrasound blood flow parameters by ultrasound, and the serum IL-6, TNF-α, and CRP levels of the women during the second trimester of pregnancy were compared among the three groups. ROC curve analysis was used to evaluate the value of umbilical artery ultrasound blood flow parameters values by ultrasound, and the serum IL-6, TNF-α, and CRP levels for predicting preeclampsia. And the diagnostic cutoff value was calculated. Results: The ultrasonographic blood flow parameters of umbilical artery, such as pulsation index (PI), resistance index (RI), and the ratio of the maximum flow velocity in systolic period (S) to the maximum flow velocity in diastolic period (D) of umbilical artery (S/D), and the serum IL-6, TNF-α, and CRP levels of the women had significant different among the three groups, and which of the women in group A were the highest, followed by those of the women in group B, and those of the women in group C were the lowest (P<0.05). ROC curve analysis showed that the values of PI, RI, and S/D, and the levels of IL-6, TNF-α, and CRP all had predictive values, which’s diagnostic cut-off values them were 1.117, 0.784, 3.902, 0.470pg/ml, 1.644ng/ml, and 6.295mg/L, respectively. The diagnostic efficacy of serum inflammatory factors (IL-6, TNF-α, and CRP) levels had relatively higher diagnostic efficacy. Conclusion: The values of umbilical artery ultrasound blood flow parameters by ultrasound (PI, RI, and S/D) and serum inflammatory factor levels (IL-6, TNF-α, and CRP) of the pregnant women during the second trimester of pregnancy have some values for predicting their preeclampsia, which should be paid to attention in the clinical secondary prevention of preeclampsia effectively.
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