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| The correlation between the levels of NK cells, CD8+ TC cells, Th1/Th2 and sex hormone in women with polycystic ovary syndrome |
| Haian People's Hospital, Jiangsu Province, 226600 |
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Abstract To study the relationship between the levels of NK cells, CD8+ TC cells and Th1/Th2 of the women with polycystic ovary syndrome (PCOS) and their sex hormone levels. Methods: 70 women with PCOS were selected in study group from February 2018 to December 2019, and another 70 women with normal ovulation were selected in control group during the same period. The differences of the values of NK cells, CD8+ TC cells, and Th1/Th2 of the women were compared between the two groups. The levels differences of the luteinizing hormone (LH), testosterone (T), follicle-stimulating hormone (FSH), estradiol (E2), and progesterone (P) of the women in the two groups were analyzed. And the correlation between the levels of NK and CD8+ TC cells, and Th1/Th2 of the women in the study group and their levels of LH, T, FSH, E2, and P was also analyzed. Results: The percentage of NK cells (14.97±4.25%) and Th1/Th2 value (44.45±10.42) of the women in the study group were significant higher than those ［(6.27±1.31) % and 20.95±5.42］ of the women in the control group, but the percentage of CD8+ TC cells (17.27±2.94%) of the women in the study group was significant lower than that (25.77±2.27%) of the women in the control group (P<0.05). The level of LH (18.58±5.61 IU/L) of the women in the study group was significant higher than that (6.55±3.99 IU/L) of the women in the control group, but the levels of E2 (69.22±1.09 pg/ml) and P (0.83±0.36 pg/ml) of the women in the study group were significant lower than those (77.02±1.23 pg/ml and 1.87±0.13 ng/ml) the women in the control group (P<0.05). There were no significant differences in the FSH and T levels of the women between the two groups (P>0.05). Correlation analysis showed that the values of NK cells, CD8+ TC cells, and Th1/Th2 cells of the women in the study group were positively correlated with their LH and T levels, and were negatively correlated with their E2 and P levels (P<0.05). Conclusion: The values of NK cells, CD8+Tc cells and Th1/Th2 were significant correlated with the sex hormone levels of the women with PCOS. The sex hormone disorder and the imbalance of immune function may be important reasons of PCOS occurrence.
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