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| The preventive value of lactobacillus vaginal capsule for premature rupture of membranes of pregnant women with vaginal microecological imbalance |
| Wanning People's Hospital, Hainan Province, 571500 |
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Abstract To analyze the effect of lactic acid bacteria vaginal capsule for reducing the incidence of premature rupture of membrane (PROM) and adverse pregnancy outcomes of pregnant women with vaginal microecological imbalance. Methods: 856 pregnant women with vaginal microecological imbalance during the third trimester of pregnancy were selected as research subjects. According to the personal willing of these women, they were divided into observation group and control group. The women in the observation group were treated with lactic acid bacteria vaginal capsule additionally. The effect of lactic acid bacteria vaginal capsule for recovering the vaginal microecology of the women were observed, the incidence of PROM of the women was compared between the two groups, and the influence of the treatment on pregnancy outcomes was analyzed. Results: The percentages of PH>4.6, hydrogen peroxide (H2O2) positive, leucocyte esterase (LE) positive, sialidase (SNA) positive, β-glucuronidase (GUS) positive, and acetylglucosaminidase positive in the vaginal secretions of the women in the observation group after treatment had decreased significantly (P<0.001). The incidence of PROM (11.1%) of the women in the observation group was significant lower than that (21.8%) of the women in the control group (P<0.05), but there was no significant difference in the percentage of full-term pregnant women with PROM between the two groups (P>0.05). As for the women with PROM, the total incidence of adverse pregnancy outcomes (37.9%) of the women with treatment was significant lower than that (66.7%) of the women without treatment (P<0.05). The incidences of premature delivery, intrauterine infection, fetal distress, chorionic amniotis, neonatal pneumonia, and puerperal infection of the women in the observation had no significant different from those of the women in the control group (P>0.05). Logistic regression analysis showed that ≥35 years old, gestational hypertension disease, gestational diabetes mellitus, and without treatment of the women with vaginal microecological imbalance during the third trimester of pregnancy were the independent risk factors of their adverse pregnancy outcomes (P<0.05). Conclusion: Lactobacillus vaginal capsule can reduce the risk of PROM of pregnant women with vaginal microecological imbalance, and can improve the pregnancy outcomes.
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