|
|
|
| Expression and clinical significances of acetaldehyde dehydrogenase 1, estrogen receptor, and progesterone receptor in endometrial carcinoma |
| 1. Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University, Jiangsu Province, 221000; 2. Xuzhou Central Hospital of Jiangsu Province |
|
|
|
|
Abstract To explore the expression of acetaldehyde dehydrogenase 1 (ALDH1), estrogen receptor (ER), and progesterone receptor (PR) in endometrial carcinoma, and to study its relevant to the clinicopathological features of endometrial carcinoma. Methods: The clinicopathologic data of 104 patients with endometrial-related disease who underwent surgery and other treatments from December 2018 to June 2020 were collected. The immunohistochemical detection method was used to detect the expressions of ER, PR, and ALDH1 in the abnormal endometrial tissues of these patients. The correlation between the ER, PR and ALDH1 levels in the abnormal endometrial tissues of the patients and their pathological features, and the diagnostic value of the ER, PR and ALDH1 levels for endometrial carcinoma were analyzed. Results: The positive rates of ER and PR in endometrial cancer tissues were significant lower than those in normal endometrial tissues, but the positive rate of ALDH1 in endometrial cancer tissues was significant higher. The positive expression rates of ER and PR in endometrial carcinoma tissues were negatively correlated with the depth of muscular invasion, pathological stage, and degree of cell differentiation of the endometrial carcinoma (P＜0.05), but which were not correlated with lymph node metastasis, menopause, or obesity of the patients (P＞0.05). Person correlation analysis had showed that the positive expression of ALDH1 in endometrial carcinoma tissues was negatively correlated with the expression of ER and PR, while the expression of ER was positively correlated with the expression of PR (P＜0.05). ROC curve analysis showed that ALDH1 level had certain diagnostic value for endometrial cancer (AUC=0.875), while ER and PR levels had low diagnostic value for endometrial cancer (AUC=0.587 and 0.666). Conclusion: The expressions of ER, PR and ALDH1 in endometrial cancer are abnormal, and the ALDH1 expression level can provide important reference for clinical diagnosis and treatment of endometrial cancer.
|
|
|
|
|
|
|
|
|
