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Abstract To investigate the influence of weight management for overweight or obese women with polycystic ovary syndrome (PCOS) on their metabolic indexes and pregnancy outcomes. Methods: 80 overweight and obese women with PCOS were selected and were divided into two groups by random number table method from January 2018 to December 2019. The women in the control group were given routinely management, and the women in the study group were given weight management except to the routinely management. The ovarian volume, waist hip ratio, body mass index, the levels testosterone (T), follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), fasting insulin (FINS), 2 h postprandial blood glucose (2hPBG), and fasting blood glucose (FBG), and interleukin 6 (IL-6), tumor necrosis factor-α(TNF-α), C-reactive protein (CRP), the value of insulin resistance index (HOMA-IR), and the situations of ovulation, menstruation recovery, and pregnancies of the women were compared between the two groups. Results: The ovarian volume (7.6±1.7 cm3), waist-hip ratio (0.8±0.1), body mass index (23.8±2.3 kg/m2), the levels of T, FSH, LH, E2, FINS, 2hPBG, FBG, IL-6, TNF-α, and CRP, and the HOMA-IR value of the women in the study group were significant less than those of the women in the control group (P＜0.05). The rates of ovulation (72.5%), menstrual recovery (80.0%), and pregnancy (97.5%) of the women in the study group were significant higher than those of the women in the control group (P＜0.05). Conclusion: Weight and diet managements for overweight or obese women with PCOS has better effectiveness, which is worthy of application.
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