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| Maternal vaginal microecological imbalance and the change of serum B7-H4, interleukin-6, and interleukin-22 levels of full-term pregnant women with premature rupture of membranes |
| 1.Jiulongpo District People's Hospital, Chongqing,400000；2. Fuling District Hospital of Traditional Chinese Medicine; 3. Sydney University of Science and Technology; 4. Jiulongpo District Health and Health Comprehensive Administrative Enforcement Detachment |
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Abstract To investigate the maternal vaginal microecological imbalance of full-term pregnant women with premature rupture of membranes (PROM), and to study the changes of their serum B7-H4, interleukin-6 (IL-6), and interleukin-22 (IL-22) levels. Methods: 96 full-term pregnant women with PROM from June 2016 to January 2020 were collected in observation group retrospectively, and 50 fullterm pregnant women without PROM were included in control group. The relationship between the PROM and the vaginal microecological change of the women was analyzed, and the changes of the serum B7-H4, IL-6, IL-22 levels of the women with PROM were also analyzed. Results: The ratios of vaginal lactobacilli (21.9%), G+ bacilli (13.5%), and G+ cocci (32.3%) of the women in the observation group were significant different from those (54.0%, 38.0%, and 6.0%) of the women in the control group. The proportion of vaginal microorganism imbalance (93.8%) of the women in the observation group was significant higher than that (60.0%) of the women in the control group. The levels of serum B7H4 (13.02±2.16ng /ml), IL-6 (28.46±6.63pg /ml), and IL-22 (43.15±6.78pg /ml) of the women in the observation group were significant higher than those of the women in the control group (P＜0.05). Conclusion: Maternal vaginal microecological imbalance of full-term pregnant women with PROM is severe. And the dominant bacteria in the vagina have also changed significantly. Serum B7-H4, IL-6, and IL-22 levels of the women increase, which may be related to the decrease of pathogen clearance ability and the enhancement of inflammatory response because of the vaginal microecological imbalance.
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