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| Effects of colonization of group B streptococcus in reproductive tract during third trimester of pregnancy on reproductive tract microecology and pregnancy outcomes |
| Wuhan Children’s Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology (Wuhan Maternal and Child Health Care Hospital), Wuhan, Hubei Province, 430015 |
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Abstract To explore the effects of colonization of group B streptococcus (GBS) in reproductive tract of pregnant women during the third trimester of pregnancy on their reproductive tract microecology and pregnancy outcomes. Methods: 876 pregnant women during the third trimester of pregnancy were selected as the research objects from January 2019 to December 2019. PCR chromatography was used to detect the colonization situation of GBS. The reproductive tract microecology of these women was tested, and pregnancy outcomes of these women were tracked. Results: Among these 876 pregnant women, the positive rate of GBS colonization was 16.9%. There were significant differences in the proportions of the vaginal cleanliness I-II (75.7% vs. 89.2%), the vaginal cleanliness III-IV (24.3% vs. 10.9%), bacterial vaginosis (6.1% vs. 2.1%), aerobic vaginitis (4.1% vs.1.1%), candida vaginitis (7.4% vs. 1.8%), respectively. There were no significant differences in the rates of imbalance of the reproductive tract bacteria distribution (17.6% vs. 5.0%) and pH>4.5 (31.8% vs. 12.1%) between the women with positive of GBS colonization and the women with negative of GBS colonization (P＜0.05). The incidences of the amniotic fluid pollution, the chorionic amniotis, the premature rupture of membranes, the intrauterine infection, the fetal distress, puerperal infection, the neonatal infection, the neonatal asphyxia, and the neonatal pneumonia of the women with positive of GBS colonization were significant higher than those of the women with negative of GBS colonization (P＜0.05). The incidences of the prenatal fever, the preterm delivery, and the neonatal septicemia had no difference between the women with positive of GBS colonization and the women with negative of GBS colonization (P＜0.05). Conclusion: The positive colonization of GBS in the reproductive tract of pregnant women during the third trimester of pregnancy may be closely related to their microecological disorders of the reproductive tract, which will increase the risk of amniotic fluid pollution, intrauterine infection, premature rupture of membranes, and poor neonatal prognosis.
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