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| The effect of dezocine combined with propofol for anesthesia of the women with induced abortion on their vital signs, stress level, and wake-up time |
| The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, 450000 |
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Abstract To explore the effect of dezocine combined with propofol for anesthesia of the women with induced abortion on their vital signs, stress level, and wake-up time. Methods: 130 women who wanted painless induced abortion were randomly divided into group A and group B (65 cases in each group). The women in group A were given propofol combined with remifentanil for anesthesia, and the women in group B were given propofol combined with dezocine for anesthesia. The wake-up time, the score of visual analogue scale(VAS) of pain, the levels of stress ［adrenocorticotropic hormone (ACTH), norepinephrine (NE), angiotensin I (A-Ⅰ), cortisol (Cor)］, the values of vital signs ［blood oxygen saturation (SpO2), heart rate (HR), and mean arterial pressure (MAP)］, and adverse reactions rate of the women were compared between the two groups. Results: There was no significant difference in postoperative wake-up time of the women between the two groups (P＞0.05). The VAS score of the women in group B was significant lower than that of the women in group A (P＜0.05), but the VAS score of the women in both groups were <4 points. The serum ACTH and A-Ⅰ levels of the women in both groups were significant higher than those of the women before surgery, but those of the women in group B were significant lower than those of the women in group A (P＜0.05). The serum NE and COR levels of the women in both groups were significant lower than those of the women before surgery, but those of the women in group B were significant higher than those of the women in group A (P＜0.05). The values of SpO2, HR, MAP, and other vital signs of the women before anesthesia, when consciousness lost, when cervix dilated, and when wake-up after surgery had no significant different between the two groups (P＞0.05). The total incidence of adverse reactions, such as respiratory depression, vomiting, nausea, bradycardia, and body movement of the women in group B was 10.8%, which was significant lower than that (26.2%) of the women in group A (P＜0.05). Conclusion: Dezocine combined with propofol for anesthesia used in induced abortion can effectively regulate the stress response of the women with lower incidence of adverse reactions, but without affecting their changes of vital signs and wake-up time.
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