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| Value of Doppler ultrasound combined with serum carcinoembryonic antigen for diagnosing endometrial carcinoma |
| Shangqiu Municipal Hospital, Henan Province, 476100 |
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Abstract To explore the value of Doppler ultrasound combined with serum carcinoembryonic antigen (CEA) level for diagnosing endometrial carcinoma. Methods: 133 women with irregular vaginal bleeding were selected as the experimental subjects from January 2016 to December 2018. According to the pathological results of these women, 63 women with endometrial carcinoma were included in observation group, and 70 women without endometrial carcinoma were included in control group. The endometrial resistance index (RI), blood flow pulsatility index (PI), and endometrial thickness of the women in the two groups were measured by color Doppler ultrasound. The level of serum CEA of the women in the two groups was detected by enzyme linked immunosorbent assay. The consistency of the results examined by color Doppler ultrasound or CEA level with pathological results were analyzed, and the diagnostic value of the results examined by color Doppler ultrasound or CEA level for endometrial carcinoma was also analyzed. Results: The values of PI and RI of the women in the observation group were significant lower than those of the women in the control group, but the endometrial thickness and serum CEA level of the women in the observation group were significant higher (P＜0.05). The Kappa value of color Doppler ultrasonography and serum CEA level were 0.694 and 0.728, which was consistent with the pathological diagnosis results as general level (0.4 ≤Kappa value <0.75). The Kappa value of the combinational detection of color Doppler ultrasonography and serum CEA level was 0.905, which’s consistency with pathological results was good (Kappa value ≥0.75). The area under the curve (AUC) of color Doppler ultrasonography combined with serum CEA level for diagnosing endometrial cancer was 0.863, the specificity and the sensitivity were 71.4% and 88.9% at the optimal cut-off value. Conclusion: Doppler ultrasonography combined with serum CEA level detection has better diagnostic value for endometrial carcinoma, which has good consistency with pathological results. It is suggested that Doppler ultrasonography and serum CEA level may be the indicators for diagnosing endometrial carcinoma.
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