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| Effects of high-risk HPV infection of infertile patients on their vaginal microecology, immune function and clinical outcomes of assisted reproduction treatment |
| Hengshui People's Hospital (Harison International Peace Hospital), Hengshui, Hebei Province, 053000 |
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Abstract To explore the effects of high-risk HPV infection of infertile patients on their vaginal microecology, immune function, and clinical outcomes after assisted reproduction treatment (ART). Methods: 60 infertility patients with high risk HPV infection after ART by fresh embryo transplantation were included in group A and 60 infertility patients without high risk HPV infection after ART by fresh embryo transplantation were included in group B from January 2018 to January 2020. The differences of vaginal microecology, the immune function, and the clinical outcomes of the patients in the two groups after ART were observed. Results: The incidences of lactobacillus abnormality, bacterial vaginitis, chlamydia, ureaplasma ureticum infection, and vaginal microecological dysregulation of the patients in group A were significant higher than those of the patients in group B (P＜0.05), but there were no differences in the infection rates of mold, mycoplasma, and trichomonas of the patients between the two groups (P＞0.05). The values of CD3+, CD4+, CD4+/CD8+ and NK of the patients in group A were significant lower than those of the patients in group B, while the CD8+ value of the patients in group A was significant higher (P＜0.05). There was no significant difference in B cells value of the patients between the two groups (P＞0.05). The values of CD3+, CD4+, CD4+/CD8+, NK of the patients were negatively correlated with their high-risk HPV infection rate (P＜0.05), but the CD8+ value was positively correlated with their highrisk HPV infection rate (P＜0.05). The distribution of CD4+/CD8+ of the patients was significant different between the two groups, the rate of distribution the value 1.1-1.9 of CD4+/CD8+ of the patients in group A was significant lower than that of the patients in group B (P＜0.05). There were no significant differences in the clinical outcomes (dosage and days of GN used, trigger day endometrium situation, number of mature eggs obtained, number of effective embryos, clinical pregnancy rate, live birth rate, abortion rate, ectopic pregnancy rate, and implantation rate) of the patients after ART between the two groups (P＞0.05). Conclusion: The high risk HPV infection of the infertile patients does not affect their clinical outcomes after ART, but it leads to vaginal microecological changes and imbalance of immune function, so HPV detection of infertile women after ART should be paid more attention to in clinical practice.
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