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| Effect of pneumoperitoneum laparoscopic oophorocystectomy for treating patients with benign ovarian cyst on their sex hormone level and immune function |
| Taizhou Municipal Hospital, Zhejiang Province, 318000 |
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Abstract To analyze the effect of pneumoperitoneum laparoscopic oophorocystectomy for treating patients with benign ovarian cyst on their sex hormone level and immune function. Methods: 114 patients with benign ovarian cyst were randomly divided into the pneumoperitoneal laparoscopic group A (57 patients with pneumoperitoneal laparoscopic oophorocystectomy) and group B (57 patients with laparotomy oophorocystectomy) according to the random number table method from March 2018 to March 2020. The patients in both groups were followed up to discharged from hospital. The operation indexes of the patients in the two groups were recorded. The levels of sex hormone before operation and 1 and 3 months after operation, and the values of immune functions indexes before operation and at the time of discharge from hospital of the patients were compared between the two groups. The complications during hospitalization of the patients in the two groups were observed. Results: The amount of intraoperative blood loss (35.5±6.9ml) of the patients in group A was significant lower than that of the patients in group B, and the time of operation (54.4±3.1min), the anal exhaust time (16.7±1.3h), and the time of postoperative getting out of bed (30.2±1.3h) of the patients in group A were significant shorter than those of the patients in group B (P＜0.05). 1 and 3 months after surgery, the serum levels of estradiol (E2) and anti-mullerin hormone (AMH) of the patients in both groups were significant lower than those before surgery. 3 months after surgery, the serum E2 and AMH levels of the patients in both groups were significant lower than those of the patients 1 month after surgery, but those of the patients in group A were significant higher than those of the patients in group B (all P＜0.05). 1 and 3 months after operation, the serum levels of follicle stimulating hormone (FSH) and luteinizing hormone (LH) of the patients in the two groups were significant higher than those before operation, but those of the patients in group A were significant lower than those of the patients in group B (P＜0.05). The serum levels of FSH and LH of the patients in group A 3 months after surgery were significant lower than those 1 month after surgery (P＜0.05). The level of serum immunoglobulin G of the patients in group A was significant higher than that of the patients in group B (P＜0.05). There was no significant differences in serum immunoglobulin A and immunoglobulin M levels of the patients between the two groups (P＞0.05). During hospitalization, the incidence of complications (5.3%) of the patients in group A was significant lower than that (17.5%) of the patients in group B (P＜0.05). Conclusion: The pneumoperitoneum laparoscopic oophorocystectomy has less influence on ovarian function and immune function of the patients with benign ovarian cyst, which can reduce intraoperative blood loss and postoperative complication rate, and is helpful to the postoperative rehabilitation of the patients.
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