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Abstract To explore the clinical effect of Jiaolai decoction combined with progesterone for treating early threatened abortion complicated with subchorionic hematoma. Methods: 90 patients with early threatened abortion complicated with subchorionic hematoma were divided into observation group and control group (45 cases in each group) according to different treatment methods from January 2018 to June 2019. The patients in the observation group were treated with Jiaoai decoction combined with progesterone, while the patients in the control group were treated with progesterone alone. The levels of prothrombin time (PT), activated partial thrombin time (APTT), D-dimer (DD), the area of subhepatic hematoma, and the side effects rate of the patients were compared between before treatment and 2 weeks after treatment. Results: 2 weeks after treatment, PT level (12.35±0.71s) of the patients in the observation group was significant higher than that (11.51±1.72s) of the patients in the control group. The levels of APTT (28.42±2.97s) and DD (0.332±0.123 μg/ml) of the patients in the observation group were significant lower than those (34.33±1.61s and 0.491±0.142μg/ml) of the patients in the control group, but the effective rate (93.3%) of the patients in the observation group was significant higher than that (73.3%) of the patients in the control group (all P＜0.05). After 2 weeks of treatment, some patients in both groups had showed early pregnant symptoms, such as nausea and retching, but the symptoms were mild and within the tolerable range, and no obvious adverse reactions were observed in both groups. There were no significantly abnormal in routine reexaminations of blood, urine and stool, the electrolyte level, and the functions of liver and kidney of the patients in both groups. Conclusion: Jiaoyai decoction combined with progesterone for treating early threatened abortion complicated with subchorionic hematoma has better curative effect with good safety and less adverse reactions.
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