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| Difference of vaginal microecological characteristics of the infertile patients with repeated embryo transfer failure and with successful embryo transfer for the first time |
| Beijing obstetrics and Gtnecdogy Hospital, Capital Medical University, Beijing, 100026 |
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Abstract To analyze the difference of vaginal microecological characteristics of the infertile patients with repeated embryo transfer failure and the infertile patients with successful embryo transfer for the first time. Methods: 77 infertile patients with repeated embryo transfer failure were selected in observation group from February 2016 to October 2019, and 80 infertile patients with successful embryo transfer for the first time were selected in control group during the same period. The differences of vaginal microecological morphology and functional characteristics of the patients were compared between the two groups. Results: The vaginal secretion flora diversity (grade I and IV), flora density (grade I and IV), and the positive rate of trichomonal test of the patients in the observation group were significant higher than those of the patients in the control group (P＜0.05), but there was no significant difference in fungal detection result of the patients between the two groups (P＞0.05). The proportion of the patients with lactobacillus as dominant bacteria and the Nugent score of the patients in the observation group were significant lower than those of the patients in the control group. The percentage of patients with vaginal PH >4.6, leukocyte esterase positive, acetylglucosaminidase positive, sialidase positive, and β-glucuronidase positive of vaginal secretion, and the level of hydrogen peroxide in vaginal secretion of the patients in the observation group were significant higher than those of the patients in the control group. The proportion of vaginal microecological dysregulation (55.8%) of the patients in the observation group was significant higher than that (13.8%) of the patients in the control group (all P＜0.05). The detection rates of intermediate type BV, BV, AV and TV of the patients in the observation group were significant higher than those of the patients in the control group (P＜0.05), but there was no significant difference in the detection rates of VVC, BV+VVC, and intermediate type BV and VVC of the patients between the two groups (P＞0.05). Conclusion: The infertility patients with repeated failure of embryo transfer have the microecological imbalance of vaginal flora, so the analysis of vaginal microflora of the infertile patients should be strengthened, and targeted treatment measures should be taken to correct their vaginal microecological imbalance in clinical practice, so as to improve the success rate of thawing embryo transfer.
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