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| Correlation between the levels of coagulation index and inflammatory factors of the women with endometriosis and their degree of pelvic adhesion |
| The First People's Hospital of Wuyi, Zhejiang Province. 321200 |
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Abstract To analyze the correlation between the levels of coagulation indicators in serum and the levels of inflammatory factors in peritoneal fluid of the women with endometriosis and their degree of pelvic adhesion. Methods: 219 women with endometriosis were selected in study group and 200 patients with benign ovarian cyst were selected in control group from February 2017 to December 2019. The plasma prothrombin time (PT), partial prothrombin time (APTT), thrombin time (TT), plasma fibrinogen (FIB), d-dimer (D-D), serum and peritoneal fluid interleukin-8 (IL-8), tumor necrosis factor-α(TNF-α), and transforming growth factor-β(TGF-β) of the women in the two groups were measured. Results：The PT and TT values of the women in the study group were significant lower than those of the women in the control group, but the FIB and D-D values of the women in the study group were significant higher (P＜0.05). The APTT value of the women had no significant difference between two groups (P＞0.05). The levels of IL-8, TNF-α and TGF-β in serum and peritoneal fluid of the women in the study group were significant higher than those of the women in the control group (P＜0.05). The PT value of the women without pelvic adhesion, the women with pelvic mild adhesion, the women with pelvic moderate adhesion, and the women with pelvic severe adhesion had decreased gradually, but the values of FIB, D-D had increased gradually. The TT value of the women with moderate or severe pelvic adhesion was significant less than that of the women without pelvic adhesion or with mild pelvic adhesion (P＜0.05), but which had no significant difference between the women with moderate pelvic adhesion and the women with severe pelvic adhesion, and between the women without pelvic adhesion and the women with mild pelvic adhesion (P＞0.05). The APTT value had no significant difference among the women with different degree of pelvic adhesion (P＞0.05). The levels of IL-8, TNF alpha, TGF-beta in serum and peritoneal fluid of the women without pelvic adhesion were the lowest, then were those of the women with mild pelvic adhesion, and then were those of the women with moderate pelvic adhesion, and those of the women with severe pelvic adhesion were the highest (P＜0.05). About the blood coagulation indexes, PT value of the women was negative correlated with their degree of pelvic adhesion (P＜0.05), FIB value and D-D value were positive correlated with their degree of pelvic adhesion (P＜0.05), and TT value was not correlated with their degree of pelvic adhesion (P＞0.05). The levels of IL-8, TNF-α and TGF-β in serum and abdominal fluid of the women were positive correlated with the degree of pelvic adhesion (P＜0.05). Conclusion: Some coagulation indexes and inflammatory factors, such as IL-8, TNF-α,and TGF-βof the women with endometriosis are related to their degree of pelvic adhesions, which can be used as a reference for preoperative evaluation.
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