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| Relationship between the grade of cervical intraepithelial neoplasia of pregnancy women with HPV infection and their adverse pregnancy outcomes |
| Liaoyang Central Hospital，Liaoyang, Liaoning Province, 111000 |
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Abstract To investigate the relationship between the grade of cervical intraepithelial neoplasia (CIN) of pregnancy women with HPV infection and their adverse pregnancy outcomes. Methods: 60 pregnant women with CIN II were enrolled in group A or women with CIN III in group B, and 50 healthy pregnant women were enrolled in control group from January 2016 to January 2019. HPV infection of the women in the groups was detected, and adverse pregnancy outcomes of the women were analyzed. Results: The positive rate of HPV of the women in group A (72.4%) had no significant different from that (87.1%) of the women in group B, which both was significant higher than that (12.0%) of the women in the control group (P＜0.05). The rate of HPV turned to negative (33.3%) of the women in group A was significant higher than that (7.4%) of the women in group B (P＜0.05). The HPV load (354.15±41.13 pg/ml) of the women in group A was significant lower than that (427.54±44.36 pg/ml) of the women in group B, and which of the women in both group A and B in postpartum 6 months was significant lower than that that of the women in both group A and B during pregnancy. The HPV load (161.12±30.25 pg/ml) of the women in group A during pregnancy was significant lower than that (235.16±31.54 pg/ml) of the women in group B (P＜0.05). The rates of adverse pregnancy outcomes of the women with HPV infection and their adverse perinatal infant outcomes were 20.8% and 10.4%, which had no significant different from those (8.3% and 8.3%) of the women without HPV infection (P＞0.05). The incidence of adverse pregnancy outcomes of the women in group B was significant higher than that of the women in the control group (P＞0.05). Conclusion: HPV infection rate of the women with CIN II or III during pregnancy is higher, and with the increase of CIN grade of the women, their HPV infection rate is increasing and the negative conversion ratio of postpartum HPV is decreasing. It suggests that HPV infection may promote the development of CIN and cervical cancer, and improve their adverse pregnancy outcomes, therefore it should be advocated to HPV infection screening of women before pregnancy, which has certain value for improving the pregnancy outcomes.
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