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Abstract To investigate the influence of early preventive use of enoxaparin sodium on the blood coagulation function and the venous thrombosis of the high-risk parturients after cesarean section. Methods: 112 high-risk parturients who underwent cesarean section were randomly divided into control group and observation group (56 cases in each group). The parturients in the control group were given routine precautions of venous thrombosis after cesarean, and the parturients in the observation group were given enoxaparin sodium at 1 day after cesarean. The occurrence of venous thrombosis parturients was compared between the two groups. The levels of coagulation function indexes including activated partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen (FIB), D-dimer (DD), platelet count (PLT), and blood rheology indexes including plasma viscosity (PV), whole blood high shear viscosity (HBV), whole blood low shear viscosity (LBV), erythrocyte deformation index (EDI) of the parturients in the two groups were measured before and 6 d after operation, and the venous blood flow velocity of the lower limbs of the parturients in the two groups was examined. Results: The incidence of lower limb venous thrombosis (1.8%) in the observation group was significant lower than that (12.5%) of the parturients in the control group (P＜0.05). At 6 days after operation, the levels of APTT, TT and PLT in the two groups had no changed significantly (P＞0.05), but the levels of D-D, FIB, PV, HBV and LBV in the observation group were significant lower than those in the control group, and EDI level in the observation was significant higher (P＜0.05). The blood flow velocities of deep femoral vein, popliteal vein, and posterior tibial vein in both groups had increased significantly, and which in the observation group were significant higher than those in the control group (P＜0.05). Conclusion: Early preventive use of enoxaparin sodium for high-risk parturients after cesarean section can improve their blood rheology parameters and venous blood flow velocity of lower limbs, which can reduce the rate of venous thrombosis without affecting coagulation function.
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