To explore the effect of ketorolac tromethamine combined with dizosin for anesthesia of women who wanted painless abortion, and to study its influence on their stress response and postoperative uterine contraction pain. Methods: 240 women with voluntary painless abortion were randomly divided into four groups: group A, group B, group C and control group (60 cases in each group) from October 2019 to March 2020. The women in group A received intravenous injection of 0.1mg/kg of dizosin at 15 minutes before abortion, the women in group B received intravenous injection of 30mg of ketorolac tromethamine at 30 minutes before abortion, the women in group C received intravenous injection of combination of 0.1mg/kg of dizosin and 30mg of ketorolac tromethamine before abortion, and the women in control group received intravenous injection of 1μg/kg of fentanyl before abortion. The anesthesia effect, relevant clinical indexes, such as operation time, propofol dosage, recovery time of directional force, recovery time after abortion, SpO2 value after anesthesia, and the hemodynamic indexes (MAP, HR) at different time points during abortion, the stress hormones levels, the uterine contraction pain score at different time points after awake, and the adverse reactions rate of the women were compared among the four groups. Results: The rate of satisfactory anesthesia (91.7%) of the women in group C was significant higher than that of the women in the other three groups (P＜0.05), but there was no significant difference in the duration of abortion among the four groups (P＞0.05). The dosage of propofol (134.3±16.4mg) of the women in group C was significant less than that of the women in the other three groups, the awakening time (4.4±1.2min) and the recovery time of directional force (4.3±1.1min) of the women in group C were significant shorter than those of the women in the other three groups, but the SpO2 value (98.6±2.3%) after anesthesia of the women in group C was significant higher than that of the women in the other three groups (P＜0.05). The levels of stress hormones at 5min after abortion begin (T1) and 5min  after abortion (T2) of the women in the four groups were significant higher than those of the women before abortion (T0), and which of the women in group C were the lowest, and which were significant less than those of the women in group A, and those of the women in group A were significant less than those of the women in group B, and those of the women in the control group were the highest. The visual analogue score of pain at 1min and 10min after waking (3.2±0.7 and 2.5±0.6) of the women in group C were significant lower than that of the women the other three groups. The incidence of adverse reaction (11.7%) of the women in group C was significant lower than that of the women the other three groups (all P＜0.05). Conclusion: The preventive application of dizosin and ketochromate tromethamine before painless induced abortion has satisfactory anesthetic effect, which can effectively reduce the dosage of propofol, decrease the fluctuation of hemodynamics and stress response, improve the effect of postoperative analgesia and the quality of resuscitation with better safety.