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| Association between MTHFR gene polymorphisms and Chinese male infertility: a meta-analysis |
| Jiangsu Health Development Research Center, Nanjing, Jiangsu Province, 210036 |
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Abstract To investigate the association between methylene tetrahydrofolate reductase gene polymorphism and male infertility in China. Methods: Chinese and English databases were searched until December 18, 2020 and a total of 19 papers included in this meta-analysis. Odds ratio, 95% confidence interval, heterogeneity, sensitivity analysis, and publication bias were calculated to evaluate the association between methylene tetrahydrofolate reductase gene polymorphism and male infertility by State software. Results: There were significant associations in the comparison T vs. C (OR=1.51, 95% CI1.34 -1.71), TC vs. CC (OR=1.13, 95% CI 1.09 -1.18), TT vs. CC (OR=2.18, 95% CI1.72-2.76), TT vs. (CC+ CT) (OR=1.81, 95%CI1.51-2.17), and (TT+ CT) vs.CC (OR=1.57, 95%CI: 1.34-1.84), which showed that MTHFR (C677T) gene polymorphism was significantly associated with male infertility in China. Conclusion: MTHFR (C677T) gene polymorphisms may increase the risk of male infertility in China.
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