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| Efficacy of HPV typing test combined with TCT for screening cervical lesions early |
| Shaanxi Provincial People's Hospital, Xi'an, Shaanxi Province, 710000 |
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Abstract To explore the clinical application value of HPV typing test combined with thinprep cytologic test (TCT) for screening cervical lesions early. Methods: The data of 418 women with suspected cervical lesions from January 2018 to January 2020 were analyzed retrospectively, which included 200 women experienced HPV typing test in control group and 218 women experienced HPV typing test combined with TCT in observation group. All these women had undergone colposcopy biopsy and the pathological examination, and which results were regarded as the "gold standard". The application value of the two detection schemes for screening of cervical lesions early was analyzed. Results: The abnormal positive rate of screening of the women in the control group (54.0%) was significant lower than that (72.5%) of the women in the observation group (P＜0.01). The positive coincidence rate of the women in the control group (75.9%) was significant lower than that (88.0%) of the women the observation group (P=0.010), but the negative predictive value of the women in the control group (95.7%) had no significant different from that (P=0.954) of the women in the observation group (P=0.954). ROC curve showed that the AUC of HPV used for detecting cervical lesions was 0.816, the specificity was 70.3%, and the sensitivity was 67.9%. The AUC of cervical lesions detected by HPV typing test combined with TCT was 0.871, the specificity was 90.2%, and the sensitivity was 88.5%. Conclusion: HPV typing test combined with TCT can improve the sensitivity, the specificity, and the efficiency of cervical lesions screening early, which has important application value in clinical screening of cervical lesions.
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