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| Value of prenatal single beat real-time three-dimensional echocardiography and two-dimensional echocardiography for screening fetal congenital heart disease |
| Pidu District Maternal and Child Health and Family Planning Service Center, Chengdu, Sichuan Province, 611730 |
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Abstract To explore the value of single beat real-time three-dimensional echocardiography (sRT-3DE) for screening fetal congenital heart disease (CHD). Methods: The clinical data of 4,786 pregnant women who underwent prenatal ultrasound examination from January to December 2019 were analyzed retrospectively. All women had accepted two-dimensional echocardiography (2DE) and sRT-3DE. The pregnant women with suspected fetal CHD were followed up. The followed up result (autopsy pathology after labor induction or postpartum ultrasound examination of infants) was as the golden standard. The diagnostic value of prenatal 2DE and sRT-3DE for fetal CHD was evaluated by Kappa consistency test. Results: There were 46 (1.0%) pregnant women with suspected fetal CHD by prenatal 2DE or sRT-3DE. Among them, there were 44 (95.7%) women with completely consistent results of prenatal sRT-3DE and followed up, and 2 (4.4%) women with suspected fetal ventricular septal defect (VSD) were confirmed that their fetus without continuous interruption of ventricular septum after birth. There were 33 (71.7%) women had completely consistent results by prenatal 2DE and by followed up. The diagnostic coincidence rate of completely consistent results by sRT-3DE was significant higher than that by 2DE (P＜0.05). The diagnostic consistency for fetal CHD was good between prenatal 2DE result and followed up result (Kappa=0.834), which’s sensitivity, specificity, and accuracy were 75.0%, 99.9%, and 99.7%, respectively. The diagnostic consistency for fetal CHD was good between prenatal sRT-3DE result and followed up result (Kappa=0. 978), which’s sensitivity, specificity, and accuracy were 100.0%, 99.9%, and 99.9%, respectively. Conclusion: sRT-3DE can improve the detection rate of CHD in the prenatal diagnosis, with higher diagnostic efficiency.
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