To investigate the relationship between the levels of umbilical cord blood procalcitonin (PCT) and interleukin-6 (IL-6) of women with different types of vaginitis during pregnancy and their risk of intrauterine infection. Methods: 122 pregnant women were enrolled in this study from January 2018 to December 2019, which included 34 women with intrauterine infection in group A and 78 women without intrauterine infection in group B. The levels of umbilical cord blood PCT and IL6 of these women were detected, and vaginitis situation of these women during pregnancy were analyzed. The relationship between different types of vaginitis and intrauterine infection status was analyzed. Results: There were no significant different in age, gravidity and parity of the women between group A and B (P＞0.05). There were significant different in the gestational weeks, the incidence of vaginal vaginitis during pregnancy, sexual behavior situation during pregnancy, the number of perinatal vaginal examination, and the course of labor of the women between group A and B. The levels of serum IL-6 (48.16±11.35ng/L) and PCT (51.16±12.44pg /ml) of the women in group A were significant higher than those (16.36±2.53ng /L and 31.25±7.89pg /ml) of the women in group B (all P＜0.05). The levels of serum IL-6 and PCT in umbilical cord blood of the women in group A were 38.34±10.37ng/L and 43.33±12.04pg/ml, which were significant higher than those (19.87±4.15ng/L and 30.02±7.11pg/ml) of the women in group B (all P＜0.05). In group A, the rate of intrauterine infection, and levels IL-6 and PCT had no significant different among the women with trichomonad vaginitis (TV), the women with vulvovaginal candidiasis (VVC), and the women with bacterial vaginosis (BV) (P＞0.05). Conclusion: Different types of vaginitis may increase the risk of intrauterine infection, so it is great significance to actively prevent and treat vaginitis during pregnancy to reduce the incidence of intrauterine infection and improve maternal and infant outcomes.