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Abstract To analyze the correlation of the level of serum Clq/tumor necrosis factor-related protein 9 (CTRP9) of women with polycystic ovary syndrome (PCOS) with their levels of glucose and lipid metabolism and total testosterone (TT), body mass index (BMI) value, and islet function. Methods: 103 women with PCOS were selected in study group from January 2019 to December 2019, and 103 healthy women were selected in control group during the same period. The levels of serum CTRP9, glucose and lipid metabolism, and TT, BMI value, and islet function of the women were compared between the two groups, and its effect on PCOS and the correlation of the serum CTRP9 level with the levels of glucose and lipid metabolism, and TT, BMI value, and islet function were analyzed. Results: The serum CTRP9 and high-density lipoprotein cholesterol (HDL-C) levels of the women in the study group were significant lower than those of the women in the control group (P＜0.05). The levels of serum fasting blood glucose (FPG), 2h postprandial blood glucose (2hPBG), triacylglycerol (TG), lowdensity lipoprotein cholesterol (LDL-C), free fatty acids (FFA), TT, and fasting insulin (FINS), and the values of BMI, pancreatic β-cell secretion index (HOMAβ), and steady state insulin evaluation index (HOMA-IR) of the women in the study group were significant higher than those of the women in the control group (P＜0.05). According to Pearson analysis had showed that the level of serum CTRP9 was positive correlated with HDL-C level, but was negative correlated with the FPG level, 2hPBG level, TG level, LDL-C level, FFA level, BMI value, TT level, FIN level, HOMA-IR value, or HOMA-βvalue were correlated (P＜0.05). Multi-factor analysis had showed that FPG level, 2hPBG level, TG level, LDL-C level, FFA level, BMI value, TT level, FIN level, HOMA-IR value, HOMA-βvalue were all the risk affecting factors of PCOS, and CTRP9 level and HDL-C level were the protective factors of PCOS. Conclusion: The blood glucose level of the women with PCOS increases, their lipid metabolism disorders, their TT level and BMI value increase, and their pancreatic islet function disorder, which all will lead to the decrease of serum CTRP9 level and affect the disease process of PCOS.
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