|
|
|
| Expression and predictive value of serum sICAM-1, PAPP-A and VEGF levels in preeclampsia |
| 1. The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan Province, 610500; 2. Sichuan Provincial People's Hospital |
|
|
|
|
Abstract To study the correlation between the expression levels of serum soluble intercellular adhesion -1 (sICAM-1), pregnancy associated plasma protein A (PAPPA), and vascular endothelial growth factor (VEGF) of the pregnant women with severity of preeclampsia (PE), and to study their predictive value for PE. Methods: 59 pregnant women with PE were selected in study group, which included 36 women with mild PE in group A, and 23 women with severe PE in group B. 30 healthy pregnant women during the same period were randomly selected in control group. The expression of serum sICAM-1, PAPP-A and VEGF of the women in the three groups were measured. The different expressions of serum sICAM-1, PAPP-A and VEGF of these women were analyzed. The correlation between the expressions levels of serum sICAM-1, PAPP-A and VEGF and the severity of PE was analyzed. Results: The serum levels of SICAM-1, PAPP-A and VEGF of the women in the study group were significant higher than those of the women in the control group (P<0.05). The levels of sICAM-1 and PAPP-A of the women in group B were the highest, but those of the women in the control group were the lowest (P<0.05). The VEGF level of the women in group B was the lowest, but that of the women in the control group was the highest (P<0.05). The levels of sICAM-1 and PAPP-A were positively correlated with the severity of PE, but the VEGF level was negatively correlated with the severity of PE (P<0.05). In the study group, the serum sICAM-1 level was positively correlated with the PAPP-A level and was negatively correlated with the VEGF level, and the PAPP-A level was negatively correlated with the VEGF level (P<0.05). The sensitivity and the specificity of the sICAM-1 level for predicting PE were 94.9% and 93.3%, which of the VEGF level for predicting PE were 73.3% and 98.3%, and which of the PAPP-A level for predicting PE were 72.9% and 93.3%. Conclusion: The expression levels of serum sICAM-1 and PAPP-A are positively correlated with the severity of PE, while VEGF level is negatively correlated with the severity of PE. The efficiency of the expression levels of serum sICAM-1, PAPP-A, and PAPP-A for predicting PE is high, which is expected to be used as evidences for monitoring PE.
|
|
|
|
|
|
|
|
|
