|
|
|
| Expression and correlation of the levels of serum MMP-9, NLRP3 and HSP70 of pregnant women with preeclampsia |
| Department of Clinical Laboratory, the 909th Hospital of Joint Logistics Support Force/The Affiliated Dongnan Hospital of Xiamen University, Zhangzhou, Fujian Province, 363000 |
|
|
|
|
Abstract To explore the expression of serum matrix metalloproteinase-9 (MMP-9), nucleotide binding oligomerization domain like receptor protein 3 (NLRP3), and heat shock protein 70 (HSP70) of pregnant women with preeclampsia, and to study their relevance to the clinical features of the women. Methods: From January 2018 to December 2019, 120 pregnant women with preeclampsia were selected in study group, and 100 normal pregnant women were selected in control group at the same time. The expression and correlation of the levels of serum MMP-9, NLRP3 and HSP70 of the women with preeclampsia were analyzed. Results: The serum NLRP3 mRNA expression level (1.56±0.57) and HSP70 level (4.12±0.52 ng/ml) of the women in the study group were significant higher than those (0.96±0.10 and 0.50±0.10 ng/ml) of the women in the control group, but the MMP-9 level (135.49±8.62 pg/ml) of the women in the study group was significant lower than that (233.25±10.24 pg/ml) of the women in the control group. The serum NLRP3 mRNA expression level and HSP70 levels of the women with early onset preeclampsia or severe preeclampsia were significant higher than those of the women with late onset preeclampsia or mild preeclampsia, but the expression level of MMP-9 of the women with early onset preeclampsia or severe preeclampsia was significant lower than that of the women with late onset preeclampsia or mild preeclampsia (all P<0.05). The levels of serum NLRP3 mRNA, MMP-9, and HSP70 expression had no significant differ among the preeclampsia women with different ages, body mass index, or gravidity and parity (P>0.05), but there were significant differences in the levels of serum NLRP3 mRNA, MMP-9, and HSP70 among preeclampsia women with different family history of preeclampsia, family history of hypertension, and urinary protein level (P<0.05). The MMP9 level was negatively correlated with the NLRP3 level (r=-0.212, P=0.020), the MMP-9 level was negatively correlated with the HSP70 level (r=-0.226, P=0.013), and the NLRP3 level was positively correlated with the HSP70 level (r=0.199, P=0.023). Conclusion: The expressions of serum NLRP3, MMP-9 and HSP70 of the pregnant women with preeclampsia are abnormal, which may be related to their family history of preeclampsia, family history of hypertension, edema status, and the urinary protein level.
|
|
|
|
|
|
|
|
|
