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| Relationship between helicobacter pylori infection of pregnant women and their pregnancy outcomes |
| Huzhou Maternity and Child Health Care Hospital, Zhejiang province, 313000 |
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Abstract To explore the relationship between helicobacter pylori (HP) infection of pregnant women and their pregnancy outcomes. Methods: The clinical data of 248 pregnant women (>20 gestational weeks) from January 2018 to February 2020 were analyzed retrospectively. The incidence of adverse pregnancy was statistically analyzed, the risk factors of adverse pregnancy outcomes were analyzed by multiple regression model, and the correlation between HP infection and adverse pregnancy outcomes was discussed. Results: Among 248 pregnant women, there were 37 women with adverse pregnancy outcomes, and the incidence rate was 14.9%. Univariate analysis showed that there were significant differences in the age, the serum progesterone level, and the rates of anemia during pregnancy, gestational diabetes mellitus (GDM), HP infection, placental abnormality, and amniotic fluid abnormality between the women with adverse pregnancy outcomes and the women with normal pregnancy outcomes (P<0.05). The incidences of low birth weight (8.1%), the total adverse pregnancy outcomes (32.6%), anemia during pregnancy (35.1%), and GDM (37.8%) of the women with HP infection were significant higher than those (0.8%, 7.2%, 14.7%, and 17.1%) of the women without HP infection (P<0.05). Logistic regression analysis showed that abnormal pregnancy history, anemia during pregnancy, GDM, HP infection, abnormal placenta, and abnormal amniotic fluid of the pregnant women were the independent risk factors of their adverse pregnancy outcomes (P<0.05). Conclusion: The incidence of HP infection of pregnant women is high. HP infection of pregnant women may interact with their anemia during pregnancy, GDM occurrence, and placental abnormality, which all jointly affect the occurrence of the adverse pregnancy outcomes.
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