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| Influence of hCG used in freeze-thaw embryo transfer cycle of women on their endometrial receptivity |
| Reproductive Center, Shenyang Women and Infant Hospital, Liaoning Province,110000 |
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Abstract To analyze the influence of human chorionic gonadotropin (hCG) used in freeze-thaw embryo transfer (FET) cycle of women on their endometrial receptivity. Methods: 488 women with FET were selected as the study subjects from January 2018 to February 2019. According to the random number and embryo transfer time, these women were divided 135 women with FET of D3 embryo and without hCG given in group A1, 109 women with FET on D5 embryo and without hCG given in group A2, 129 women with FET of D3 embryo and with hCG given in group B1, and 115 women with FET of D5 embryo and with hCG given in group B2. The hemodynamics indexes, blood flow indexes, and clinical outcomes of the women were compared among these groups. Results: On hCG day, the endometrial thickness, the values of uterine spiral artery S/D, RI, PI, endometrial V, and endometrial blood flow VI, FI and VFI of the women had no significant differences between group A1 and B1 (P>0.05). On the embryo transfer day, the endometrial thickness, the values of endometrial V, and endometrial blood flow group VI, FI and VFI of the women in group A1 were significant lower than those of the women in group B1, but the values of uterine spiral artery S/D and RI of the women in group A1 were significant higher than those the women in group B1 (all P<0.05). There were no significant differences in endometrial classification, uterine spiral artery PI value, and the rates of biochemical pregnancy, early abortion, and ectopic pregnancy of the women between group A1 and B1 (P>0.05). The rates of embryonic implantation and clinical pregnancy of the women in group A1 were significant lower than those of the women in group B1 (P<0.05). On HCG day, there were no significant differences in endometrial classification, endometrial thickness, the values of uterine spiral artery S/D, RI and PI, endometrial V, and endometrial blood flow VI, FI and VFI of the women between group A2 and group B2 (P>0.05). On the embryo transfer day, the endometrial thickness, the values of endometrial V, and endometrial blood flow FI and VFI of the women in group A2 were significant lower than those of the women in group B2, but the uterine spiral artery RI value of the women in group A2 was significant higher (all P<0.05). There were no significant differences in the values of the uterine spiral artery S/D and PI, and endometrial blood flow VI of the women between group A2 and B2 (P>0.05). The embryo implantation rate and clinical pregnancy rate of the women in group A2 were significant lower than those of the women in group B2 (P<0.05), but there were no significant differences in biochemical pregnancy rate, early abortion rate, and ectopic pregnancy rate of the women between group A2 and B2 (P>0.05). Conclusion: hCG used in the women with FET can improve their endometrial receptivity by improving their endometrial perfusion in FET cycle.
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