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| Analysis of correlation between vaginal microbiological metabolites and endometriosis occurrence |
| 1, Jianggan District People's Hospital of hangzhou City, Zhejiang Province, 310016； 2. The Second Hospital of Heilongjiang Province |
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Abstract To analyze the characteristics of vaginal microbiological metabolites of women with endometriosis (EMS), and to study its correlation with their clinical features. Methods: The women with EMS were selected in observation group from February 2017 to July 2020, and the healthy women were selected in control group during the same period. The operative stage, dysmenorrhea degree, and serum CA125 level of the women in the observation group were evaluated. Dry chemical enzyme method was used to detect vaginal microecological environment. The difference of vaginal microecological environment detection results of the women was compared between the two groups. The vaginal microecological function characteristics of the women in the observation group and its correlation were analyzed according to their operative stage (r-AFS stage), dysmenorrhea degree, and serum CA125 level. Results: The positive rates of H2O2 (70.3%) and β-glucuronase (GUS, 38.0%) of the women in observation group were significant higher than those (51.5% and 25.4%) of the women in control group, and the positive rates of H2O2 and GUS of the women with r-AFS stage I, II and III-IV were gradually increased (all P<0.05). The positive rates of LE, NAG and SNA of the women had no significant different between the two groups (P>0.05). The positive rates of H2O2 and GUS had no significant different between the women with visual analogue scale (VAS) score ≤5 and women with VAS score 6-10, and between the women with serum CA125 level≤50U/mL and the women with serum CA125 level >50U/mL (P>0.05). The r-AFS stage of operation was positively correlated with the positivity of H2O2 and GUS (P<0.05), while VAS score and serum CA125 level had no correlation with the positivity of H2O2 and GUS (P>0.05). Conclusion: The imbalance of vaginal microecological environment may be related to the occurrence and development of EMS of women.
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