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| Changes of the levels of serum progesterone, human chorionic gonadotropin, and human placental lactogen of women during the first trimester of pregnancy and their correlation with adverse pregnancy outcomes |
| 1.Dalian Maternal and Child Health Care hospital, Liaoning Province, 116021; 2.Yinchuan Maternal and Child Health Care hospital, Ningxia Hui Autonomous Region |
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Abstract To analyze the changes of the levels of serum progesterone (P), human chorionic gonadotropin (HCG), and human placental lactogen (HPL) of women during the first trimester of pregnancy, and to study their cor- relation with adverse pregnancy outcomes. Methods: 89 pregnant women with adverse pregnancy outcomes in the study group from March 2017 to April 2019 were collected retrospectively, which included 39 cases with threatened abortion in group A, 21 cases with termination of pregnancy during the first trimester of pregnancy in group B, and 29 cases with ectopic pregnancy in group C. In addition, 89 normal pregnant women were selected in control group during the same period. The levels of HCG, P, and HPL of the women during 6 and 8 gestational weeks were compared among these groups. The correlation between the levels of HCG, P, and HPL of the women and their adverse pregnancy outcomes was analyzed. Results: The levels of HCG, P, and HPL of the women in the control group during 6 and 8 gestational weeks were significant higher than those of the women in the study group (P<0.05). In the study group, the levels of HCG, P, and HPL of the women in group A during 6 gestational weeks were the highest, and those of the women in group B were the lowest. The levels of HCG, P, and HPL of the women in group A and in the control group during 8 gestational weeks were significant higher than those during 6 gestational weeks (all P<0.05). Multivariate analysis showed that age over 28 years old, previous history of abortion, pregnancy times >2 times, gestational diabetes mellitus, abnormal levels of HCG, P, and HPL were the independent risk factors of the adverse pregnancy outcomes of pregnant women (P<0.05). Conclusion: The levels of HCG, P, and HPL of the women with abnormal pregnancy during the first trimester of pregnancy are lower than those of the normal pregnant women. Dynamically monitoring the levels of HCG, P, and HPL of the pregnant women can help prevent the occurrence of adverse pregnancy outcomes.
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