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| The changes of serum CK, HCG and SFlt-1 levels of women with placenta accreta and its correlation with the blood flow parameters examined by threedimensional ultrasound |
| Shunyi Hospital of Beijing Traditional Chinese Medicine, Beijing, 101300 |
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Abstract To investigate the correlation between the changes of the levels of serum creatine kinase (CK), human chorionic gonadotropin (HCG) and soluble fms-like tyrosine kinase receptor 1 (sFlt-1) of women with placenta accreta (PA) and their blood flow parameters examined by three-dimensional ultrasound. Methods: 274 pregnant women were selected and divided into study group (22 cases with PA) and control group (252 cases without PA) according to the found during delivery. The factors affecting the occurrence of PA were analyzed. The correlation between serum indexes and the blood flow parameters examined by threedimensional ultrasound was analyzed, and the predictive value of serum indexes for severe PA was also analyzed. Results: Age ≥35 years old, pregnancy≥4 times, birth≥1 times, induced abortion≥2 times, history of cesarean section, placenta previa, abnormally elevated of serum CK and hCG levels, and abnormally decreased of serum sFLT-1 level were all the risk factors of PA occurrence (P<0.05). The AUC value (0.878) of the combination of the serological indexes and the blood flow parameters examined by three-dimensional ultrasound of the women for predicting severe PA was the highest, and which’s sensitivity and specificity were 85.7% and 85.7%. Conclusion: The serum CK, HCG, and SFlt-1 levels of pregnant women with PA are abnormal. The combination of the serum CK, HCG, and SFlt-1 levels and the blood flow parameters examined by three-dimensional ultrasound is helpful to improve the evaluation efficiency of diagnosing PA.
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